A Comparative Study of Analgesic Effect of Ultrasound Guided Erector Spinae Plane Block Versus Quadratus Lumborum Block for Open Colorectal Cancer Surgeries
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 68
- 试验地点
- 1
- 主要终点
- Postoperative pain score
研究概览
简要总结
Colorectal cancer is the third most common cancer worldwide. These patients usually undergo open surgical resection of cancer under general anaesthesia.
The aim of this study is to detect whether the Erector spinae plan block or Quadratus lumborum block will provide the most ideal analgesia for these patients. Erector spinae plan block is a novel analgesic technique that provides both visceral and somatic analgesia due to its communication with the paravertebral space. Quadratus lumborum block is a truncal nerve block usually used for intra-abdominal surgeries. Ultrasound guidance increases the accuracy and safety of both techniques. A local anaesthetic mixture of Bupivacaine 0.25% and dexamethasone will be used for both techniques.
详细描述
Erector spinae plane block and quadratus lumborum block are analgesic techniques suitable for open colorectal cancer surgeries. postoperative pain score, serum levels of biomarkers of stress (cortisol and CRP), primary hemodynamics, time to first rescue analgesic request, the total amount of rescue analgesic consumption and postoperative nausea and vomiting are the parameters of comparison between both techniques.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Single (Participant)
盲法说明
Single blind (participant) study
入排标准
- 年龄范围
- 40 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •American Society of Anesthesiologists physical status I or II
- •Body mass index from 18.5 to 35 Kg/m2
排除标准
- •Body mass index more than 35 Kg/m
- •Severe or uncompensated cardiovascular disease.
- •Severe renal disease.
- •Severe hepatic disease.
- •Severe endocrinal disease.
- •Pregnancy.
- •Postpartum.
- •Lactating females
- •Allergy to one of the agents used.
- •Refusal to participate in the study.
研究组 & 干预措施
Erector spinae plane block
Patients will receive bilateral ultrasound-guided erector spinae plane block as an adjuvant analgesic technique
干预措施: Erector spinae plane block (Other)
Erector spinae plane block
Patients will receive bilateral ultrasound-guided erector spinae plane block as an adjuvant analgesic technique
干预措施: Propofol (Drug)
Erector spinae plane block
Patients will receive bilateral ultrasound-guided erector spinae plane block as an adjuvant analgesic technique
干预措施: Fentanyl NCS (Drug)
Erector spinae plane block
Patients will receive bilateral ultrasound-guided erector spinae plane block as an adjuvant analgesic technique
干预措施: Atracurium Injectable Product (Drug)
Erector spinae plane block
Patients will receive bilateral ultrasound-guided erector spinae plane block as an adjuvant analgesic technique
干预措施: Endotracheal intubation (Other)
Erector spinae plane block
Patients will receive bilateral ultrasound-guided erector spinae plane block as an adjuvant analgesic technique
干预措施: Anesthesia Maintenance (Drug)
Erector spinae plane block
Patients will receive bilateral ultrasound-guided erector spinae plane block as an adjuvant analgesic technique
干预措施: Muscle Relaxation (Drug)
Quadratus lumborum block
Patients will receive bilateral ultrasound-guided quadratus lumborum block as an adjuvant analgesic technique
干预措施: Quadratus lumborum block (Other)
Quadratus lumborum block
Patients will receive bilateral ultrasound-guided quadratus lumborum block as an adjuvant analgesic technique
干预措施: Propofol (Drug)
Quadratus lumborum block
Patients will receive bilateral ultrasound-guided quadratus lumborum block as an adjuvant analgesic technique
干预措施: Fentanyl NCS (Drug)
Quadratus lumborum block
Patients will receive bilateral ultrasound-guided quadratus lumborum block as an adjuvant analgesic technique
干预措施: Atracurium Injectable Product (Drug)
Quadratus lumborum block
Patients will receive bilateral ultrasound-guided quadratus lumborum block as an adjuvant analgesic technique
干预措施: Endotracheal intubation (Other)
Quadratus lumborum block
Patients will receive bilateral ultrasound-guided quadratus lumborum block as an adjuvant analgesic technique
干预措施: Anesthesia Maintenance (Drug)
Quadratus lumborum block
Patients will receive bilateral ultrasound-guided quadratus lumborum block as an adjuvant analgesic technique
干预措施: Muscle Relaxation (Drug)
结局指标
主要结局
Postoperative pain score
时间窗: From 1 day before the surgery to the 2 days after surgery
The intensity of pain indicated by a segmented numeric scale in which a respondent selects a whole number (0-100 integers) that best reflects his/her pain as 0-30 for mild pain, 30-60 for moderate pain and 60-100 for sever pain
次要结局
- Systolic Blood Pressure(One hour before induction of general anesthesia, every 10 minutes till end of surgery, every 4 hours till end of the first 24 hours postoperatively, then every 8 hours till end of the next 24 hours)
- Peripheral oxygen saturation(One hour before induction of general anesthesia, every 10 minutes till end of surgery, every 4 hours till end of the first 24 hours postoperatively, then every 8 hours till end of the next 24 hours)
- Time to first rescue analgesic request(Up to 48 postoperative hours)
- Serum C-reactive protein (CRP)(On hospital admission, 1 hour after induction of general anesthesia, 1st, 24th and 48th hours postoperatively)
- Postoperative nausea and vomiting intensity score(Immediately after recovery, every 4 hours till end of the first 24 hours postoperatively, then every 8 hours till end of the next 24 hours)
- Heart rate(One hour before induction of general anesthesia, every 10 minutes till end of surgery, every 4 hours till end of the first 24 hours postoperatively, then every 8 hours till end of the next 24 hours)
- Mean Blood Pressure(One hour before induction of general anesthesia, every 10 minutes till end of surgery, every 4 hours till end of the first 24 hours postoperatively, then every 8 hours till end of the next 24 hours)
- Total amount of rescue analgesic consumption(From the time of first analgesic request till the end of the first 24 hours, then till the end of the next 24 hours postoperatively)
- Cortisol(At 9 Am, 1 hour after induction of general anesthesia, 1st, 24th and 48th hours postoperatively)