Comparative study of the stability of oral anticoagulant therapy using phenprocoumon or warfarin.

Completed

• Conditions: Anticoagulant treatment; Haematological Disorders; Other coagulation defects

• Registration Number: ISRCTN60446748
• Lead Sponsor: eiden University Medical Centre (LUMC) (Netherlands)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2005-12-20
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

1. No current use of anticoagulants
2. Aged 18 to 85 years
3. Indication for the use of oral anticoagulants
4. Living in the working area of the Leiden Anticoagulation Clinic
5. Adequate intelligence, informed consent

Exclusion Criteria

1. Pregnancy
2. Chemotherapy
3. Haemo- or peritoneal dialysis
4. Plasmapheresis
5. Contra-indication for the use of oral anticoagulants

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Time spent within therapeutic range, time to the first international normalised ratio (INR) in range, percentage of INRs above range after initiation scheme, reaction of INR to interruption of coumarin or vitamin K administration.

Secondary Outcome Measures

Name	Time	Method
1. Bleeding complications<br>2. Thrombotic complications