Split Renal Function Using 99mTc-DTPA Versus 99mTc-DMSA in Kidney Patients of Wide Age Ranges.

Not Applicable

• Conditions: The Difference in Estimation of Split Renal Function Using the Two Radiopharmaceuticals:Tc-99m DTPA & Tc-99m DMSA in Kidney Patients
• Interventions: Other: renal scintigraphy

• Registration Number: NCT03879005
• Lead Sponsor: Assiut University

Brief Summary

To evaluate split renal function using Tc-99m DTPA versus Tc-99m DMSA.

Detailed Description

Split renal function (SPR) is a determination of the relative contribution of each of the two kidneys . It gives a useful information in several conditions such as evaluating unilateral renal disorders, assessing individual kidney function before and after intervention, and before live donor nephrectomy. Different radiopharmaceuticals such as technetium-99m dimercaptosuccinic acid (99mTc-DMSA), technetium-99m diethylenetriaminepentaaceticacid (99mTc-DTPA), technetium-99m mercaptoacetyltriglycine (99mTc-MAG3), Iodine 131 orthoiodohippurate and more recently technetium-99 m ethylenedicysteine (99mTc-EC) were used, However, 99mTc-DMSA as a static renal agent is considered the most reliable method to measure relative renal function and the most appropriate tracer for renal cortical imaging . In some papers, it is emphasized that relative renal function calculated with 99mTc-DTPA is as reliable as 99mTc-DMSA .‬ The investigators design the study to evaluate the difference in estimation of split renal function using the available two radiopharmaceuticals: Tc-99m DTPA and Tc-99m DMSA.

Study Timeline

• Status Verified: 2019-03
• Study First Submitted: 2019-03-08
• Study First Submitted QC: 2019-03-15
• Study First Posted: 2019-03-18
• Last Update Submitted: 2019-03-19
• Last Update Posted: 2019-03-21
• Study Start: 2019-04
• Primary Completion: 2019-09
• Study Completion: 2019-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

1. Kidney patients of wide age ranges.
2. Patients with renal disorders who referred for DMSA and DTPA split renal function.
3. Patients able to sleep in a fixed position for 20 minutes.

Exclusion Criteria

1. Children unable to sit calm without movement during imaging.
2. Severely ill patients.
3. Patients with allergy to one or more of material method.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Renal scintigraphy	renal scintigraphy	5 mci of 99mTc-DTPA or 99mTc-DMSA is injected once IV. Dose is adjusted according to age and weight.

Primary Outcome Measures

Name	Time	Method
Split renal function using 99mTc-DTPA versus 99mTc-DMSA in kidney patients of wide age ranges.	one year	To emphasize that split renal function calculated with Tc-99m DTPA is as reliable as Tc-99m DMSA