Split Renal Function Using 99mTc-DTPA Versus 99mTc-DMSA in Kidney Patients of Wide Age Ranges
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Assiut University
- Enrollment
- 25
- Primary Endpoint
- Split renal function using 99mTc-DTPA versus 99mTc-DMSA in kidney patients of wide age ranges.
Study Overview
Brief Summary
To evaluate split renal function using Tc-99m DTPA versus Tc-99m DMSA.
Detailed Description
Split renal function (SPR) is a determination of the relative contribution of each of the two kidneys . It gives a useful information in several conditions such as evaluating unilateral renal disorders, assessing individual kidney function before and after intervention, and before live donor nephrectomy. Different radiopharmaceuticals such as technetium-99m dimercaptosuccinic acid (99mTc-DMSA), technetium-99m diethylenetriaminepentaaceticacid (99mTc-DTPA), technetium-99m mercaptoacetyltriglycine (99mTc-MAG3), Iodine 131 orthoiodohippurate and more recently technetium-99 m ethylenedicysteine (99mTc-EC) were used, However, 99mTc-DMSA as a static renal agent is considered the most reliable method to measure relative renal function and the most appropriate tracer for renal cortical imaging . In some papers, it is emphasized that relative renal function calculated with 99mTc-DTPA is as reliable as 99mTc-DMSA . The investigators design the study to evaluate the difference in estimation of split renal function using the available two radiopharmaceuticals: Tc-99m DTPA and Tc-99m DMSA.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Diagnostic
- Masking
- None
Eligibility Criteria
- Ages
- 2 Months to 80 Years (Child, Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Kidney patients of wide age ranges.
- •Patients with renal disorders who referred for DMSA and DTPA split renal function.
- •Patients able to sleep in a fixed position for 20 minutes.
Exclusion Criteria
- •Children unable to sit calm without movement during imaging.
- •Severely ill patients.
- •Patients with allergy to one or more of material method.
Arms & Interventions
Renal scintigraphy
5 mci of 99mTc-DTPA or 99mTc-DMSA is injected once IV. Dose is adjusted according to age and weight.
Intervention: renal scintigraphy (Other)
Outcomes
Primary Outcomes
Split renal function using 99mTc-DTPA versus 99mTc-DMSA in kidney patients of wide age ranges.
Time Frame: one year
To emphasize that split renal function calculated with Tc-99m DTPA is as reliable as Tc-99m DMSA
Secondary Outcomes
No secondary outcomes reported
Investigators
Marwa Fathy
Principle investigator
Assiut University