Comparison of Ascorbic Acid and Grape Seed Extract in Oxidative Stress Induced by on Pump Heart Surgery
Not Applicable
- Conditions
- CABG-Induced Oxidative Stress
- Interventions
- Drug: GSEDrug: Vit C (Ascorbic Acid)
- Registration Number
- NCT00839085
- Lead Sponsor
- Tabriz University
- Brief Summary
Study aimed to compare the effect of grape seed extract and ascorbic acid in oxidative stress induced by on pump coronary artery by pass grafting surgery.
- Detailed Description
This study aimed to compare the effect of grape seed extract and ascorbic acid in oxidative stress induced by on pump coronary artery by pass grafting surgery.
There are three groups in the study. 75 candidate of coronary artery by pass grafting surgery were assigned random allocation on the groups (25 in each group).
1. Control
2. GSE (100 mg/6h - PO, 24h before surgery)
3. Vit C (25 mg/kg in pump circulation during surgery)
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 72
Inclusion Criteria
- Candidates for elective CABG surgery with pump for first time
- 3VD
Exclusion Criteria
- High risk patients
- Those who need another heart surgery beside CABG
- Urgent patients
- Diabetics
- Ischemic time more than 120 min
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 2: GSE GSE 100 mg GSE every 6h /Po, starting one day before surgery (4 doses in 24h) 3: Vit C Vit C (Ascorbic Acid) 25 mg/kg through pump
- Primary Outcome Measures
Name Time Method LVEF Before and after CABG
- Secondary Outcome Measures
Name Time Method Total Antioxidant Capacity (TAC) Before ischemia, after ischemia, after reperfusion MDA Before, middle and after CABG GTX Before ischemia, after ischemia, after reperfusion SOD Before ischemia, after ischemia, after reperfusion
Trial Locations
- Locations (1)
Cardiovascular Research Center
🇮🇷Tabriz, East Azerbaijan, Iran, Islamic Republic of