Frequency of Respiratory Acidosis and Alkalosis in the Emergency and Intensive Care Department of the IUCPQ-UL. Potential Impact of the Use of the Application VentilO
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- acid-base abnormalities on arterial (or capillary) blood gases
研究概览
简要总结
Mechanical ventilation is a vital support associated with the treatment of patients with acute respiratory failure and in other indications such as surgery under general anesthesia, coma or shock. Optimization of settings during mechanical ventilation and implementation of protective ventilation help to avoid ventilation-induced injury, ensure adequate oxygenation and maintain adequate carbon dioxide concentration to avoid respiratory acidosis or alkalosis.
Similarly, there is also no clear recommendation, to our knowledge, for the initial setting of the respiratory rate. Therefore, initial settings are not always adequate and in the literature the frequency of respiratory acidosis is very high, reaching about half of the patients receiving mechanical ventilation.
VentilO, is an application that is available on smart phones. This educational application provides clinicians with initial settings and optimization of these settings based on gender, height, weight, body temperature and patient type. The algorithm used is based on published data regarding ventilatory requirements in different populations and the anatomical and instrumental dead space of patients.
The purpose of our study is to:
- Assess whether ventilatory settings after intubation are appropriate.
- To compare the ventilatory adjustments made by clinicians with those proposed by the VentilO appalication.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults (> or = 18 years old)
- •New endotracheal intubation
排除标准
- •Absence of arterial (or capillary) gas within two hours of intubation
- •Absence of patient sizes available throughout the medical record
结局指标
主要结局
acid-base abnormalities on arterial (or capillary) blood gases
时间窗: on the first result available of arterial(or capillary) blood gases after intubation; 2 hours maximum post intubation
evaluate the frequency of acid-base abnormalities, either acidosis or alkalosis, of respiratory or mixed origin on the first arterial gases after intubation. Respiratory acidosis is defined as a pH \< 7.35 with a PaCO2 \> 45 mmHg, and respiratory alkalosis as a pH \> 7.45 with a PaCO2 \< 35 mmHg)
Improvement acid-base abnormalities with the VentilO application
时间窗: on the first result available of arterial(or capillary) blood gases after intubation; 2 hours maximum post intubation
* In case of respiratory acidosis: minute ventilation proposed by VentilO \> set minute ventilation; * In case of respiratory alkalosis: proposed minute ventilation by VentilO \< set minute ventilation
Impairement acid-base abnormalities with the VentilO application
时间窗: on the first result available of arterial(or capillary) blood gases after intubation; 2 hours maximum post intubation
* In case of respiratory acidosis: proposed minute ventilation by VentilO \< set minute ventilation * In case of respiratory alkalosis: minute ventilation proposed by VentilO \> set minute ventilation
次要结局
- ICU length of stay(up to 90 days. ICU stay - ICU admission through ICU discharge or until death if occured)
- Severity of unbalance of arterial (or capillary) blood gases result(on the first result available of arterial(or capillary) blood gases after intubation; 2 hours maximum post intubation)
- Hospital length of stay(up to 90 days. ICU stay - Emergency department admission through hospital discharge or until death if occured)
- ICU mortality(up to 90 days. ICU admission through until death if occured)
- Occurence of optimal arterial (or capillary) blood gases result(on the first result available of arterial(or capillary) blood gases after intubation; 2 hours maximum post intubation)
- hemodynamic instabilities(Between Hour0 to Hour1 after intubation)
研究者
François Lellouche
Principal Investigator
Laval University