Confocal Laser Endomicroscopy for in Vivo Molecular Imaging of Gastric Cancer by Targeting MG7 Antigen
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 5
- 试验地点
- 1
研究概览
简要总结
The study aims to:
- Achieve molecular imaging of MG7 antigen in patients with gastric cancer in vivo using confocal laser endomicroscopy.
- Compare the results of in vivo MG7-specific molecular imaging with CLE and ex vivo immunohistochemistry .
详细描述
Gastric cancer remains the world's second leading cause of cancer-related death. Improved prognosis essentially depend on earlier diagnosis. Gastric monoclonal antibody MG7 has been validated as a specific antibody in gastric cancerous tissue. Conventional evaluation of MG7 antigen expression is immunohistochemistry, which is time-consuming, and the immunoreactivity can be affected by storage and fixation of tissue. Confocal laser endomicrosopy enables visualization of the cellular and subcellular structures in vivo. Thus this study aims to achieve molecular imaging of MG7 antigen in gastric cancer in vivo using confocal laser endomicroscopy.
研究设计
- 研究类型
- Observational
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with endoscopically diagnosed gastric cancer
排除标准
- •Patients who are allergic to fluorescein sodium
- •Patients who are unwilling to sign or give the informed consent form
- •Patients with giant tumors or obvious GI tract bleeding which make it hard or impossible to observe the lesions
- •Patients with impaired cardiac, liver or renal function
- •Patients with coagulopathy
- •Patients with pregnancy or breastfeeding
研究者
Yanqing Li
Chief of the Department of Gastroenterology, Qilu Hospital, Shandong University
Shandong University