Comparison of different sample types for respiratory microbiome analysis using the ISpro technology

• Conditions: J44.9; J18; J45; C34; J84.9; E84; Pneumonia, organism unspecified; Chronic obstructive pulmonary disease, unspecified; Asthma; Malignant neoplasm of bronchus and lung

• Registration Number: DRKS00022094
• Lead Sponsor: Pneumologie/Allergologie, Medizinische Klinik 1, Universitätsklinikum Frankfurt – Goethe-Universität

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-06-12
• Study Completion: 2021-10-21
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Part 1
Written informed consent, In- or outpatient at the Department of Respiratory Medicine, University Hospital Frankfurt, Existing diagnosis of one or more of the following: pneumonia, chronic obstructive pulmonary disease, asthma, lung carcinoma, interstitial lung disease, cystic fibrosis
Part 2
Written informed consent, Scheduled bronchoscopy with bronchoalveolar lavage

Exclusion Criteria

Suspected or confirmed pulmonary infection with a pathogen of risk group 3 or higher (e.g., Mycobacterium tuberculosis) as published by Committee on Biological Agents / German Federal Institute of Occupational Safety and Health,

Inability to understand the nature, scope, and possible consequences of the study

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
First part of the study: Improving the detection of airway bacteria by ISpro technology.<br><br>Second part of the study:<br>Demonstrate that throat-/ nose-swabs or sputum samples are a viable alternative to bronchoalveolar lavage for analyzing the airway microbiome by ISpro technology