NCT00292721已完成4 期
Effects of Celecoxib on Restenosis After Percutaneous Coronary Intervention and Evolution of Atherosclerosis (COREA) Trial
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 260
- 试验地点
- 1
- 主要终点
- Late luminal loss at 6 months
研究概览
简要总结
Several studies including ours have reported that celecoxib improves endothelium-dependent vasodilation and reduces inflammation and neointimal hyperplasia. Our hypothesis is that celecoxib may reduce the late luminal loss after coronary stent implantation (paclitaxel-eluting stent.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Coronary artery disease with at least 1 de novo lesion greater than 50% stenosis on coronary angiography
排除标准
- •Acute ST elevation MI
- •Left main disease
- •Contraindications to aspirin, clopidogrel or celecoxib
- •Severe congestive heart failure
- •Expected survival < 2 years
- •Hepatic dysfunction
- •Currently taking NSAIDs or any COX-2 inhibitor
- •Renal dysfunction
- •Use of warfarin
研究组 & 干预措施
Celecoxib
Active Comparator
干预措施: Celecoxib (Drug)
结局指标
主要结局
Late luminal loss at 6 months
时间窗: 6 months
次要结局
未报告次要终点
研究者
研究点 (1)
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