Spinal Metastasis as the First Presentation of Lung Malignancy: Clinical Characteristics and Postoperative Survival

Completed

• Conditions: Lung Cancers; Bone Metastasis

• Registration Number: NCT07100444
• Lead Sponsor: Guangdong Provincial People's Hospital

Brief Summary

The aim of this study is to compare the clinical features and postoperative survival outcomes between patients with spinal metastasis as the initial manifestation of malignancy and those with spinal metastasis occurring after an established diagnosis of malignancy.

Detailed Description

The aim of this study is to compare the clinical features and postoperative survival outcomes between patients with spinal metastasis as the initial manifestation of malignancy and those with spinal metastasis occurring after an established diagnosis of malignancy. By analyzing and contrasting these two groups, we seek to identify any distinctive characteristics, prognostic factors, and potential implications for early detection and treatment strategies in patients with malignant spinal metastases.

Study Timeline

• Study Start: 2018-01-01
• Primary Completion: 2025-03-30
• Study Completion: 2025-04-30
• Status Verified: 2025-07
• Study First Submitted: 2025-07-24
• Study First Submitted QC: 2025-07-27
• Last Update Submitted: 2025-07-27
• Study First Posted: 2025-08-03
• Last Update Posted: 2025-08-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 139

Inclusion Criteria

1. Age ≥ 18 years.
2. Pathologically or radiologically confirmed diagnosis of lung cancer with spinal metastasis.
3. Patients with spinal metastasis who underwent surgical intervention.
4. Adequate medical records and follow-up data available.

Exclusion Criteria

1. Patients with spinal metastasis originating from non-lung primary tumors.
2. Patients who did not receive surgical treatment for spinal metastasis.
3. Incomplete clinical data or lost to follow-up.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Postoperative Overall Survival	From the date of surgery until death or last follow-up, up to 5 years	Postoperative overall survival is defined as the time from the date of surgery for spinal metastasis to the date of death from any cause. Patients who are still alive at the last follow-up will be censored at that date. Survival status will be ascertained by clinical follow-up and/or review of medical records.

Trial Locations

Locations (1)

Guangdong Provincial People's Hospital; 🇨🇳 Guangzhou, Guangdong, China