The Effect of Succinylated Gelatin on the Blood Viscosity and Oxygen Delivery
Phase 4
- Conditions
- Blood Viscosity
- Interventions
- Drug: Ringer's lactate solution
- Registration Number
- NCT02631356
- Lead Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
- Brief Summary
The study is to investigate the effect of succinylated gelatin on the blood viscosity and oxygen delivery in patients during surgeries, so as to have a better understanding of the safety in the use of succinylated gelatin for surgical patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 12
Inclusion Criteria
- Patients between the ages of 18 years and 60 years
- ASA physical status I and II
- surgical procedures requiring general anesthesia with continuous CVP and arterial pressure monitoring
Exclusion Criteria
- Patients younger than 16 y or older than 60 y
- Body Mass Index (BMI) <18 or >30
- Allergy to any of the drugs used
- Severe cardiovascular dysfunction
- Patient refusal
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Ringer's lactate solution Ringer's lactate solution Infusion of Ringer's lactate solution (10ml/kg) in the control group Succinylated gelatin Succinylated gelatin Infusion of Succinylated gelatin (10ml/kg) in the test group
- Primary Outcome Measures
Name Time Method The patient's arterial blood viscosity (mpa.s) as tested by viscometer up to 5 months (after the infusion of succinylated gelatin )
- Secondary Outcome Measures
Name Time Method The patient's oxygen delivery index (DO2I) as calculated by Vigileo up to 5 months (after the infusion of succinylated gelatin )
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms does succinylated gelatin employ to alter blood viscosity and enhance oxygen delivery in surgical patients?
How does succinylated gelatin compare to Ringer's lactate in modifying blood viscosity and oxygen delivery during surgery?
What biomarkers predict response to succinylated gelatin in surgical patients with altered blood viscosity?
What are the potential adverse events associated with succinylated gelatin use in surgical settings and how are they managed?
What are the therapeutic advantages of succinylated gelatin over other plasma expanders like hydroxyethyl starch in surgical patients?
Trial Locations
- Locations (1)
The First Affiliated Hospital of Sun Yat-Sen University
🇨🇳Guangzhou, Guangdong, China