ISRCTN15521056CompletedPhase 2
Chemoradiation for irresectable (T4) oesophageal cancer: a phase II multicentre study
Erasmus Medical Centre (The Netherlands)0 sites54 target enrollmentStarted: February 27, 2007Last updated:
Conditions
Trial Snapshot
- Phase
- Phase 2
- Status
- Completed
- Sponsor
- Enrollment
- 54
Study Overview
Brief Summary
2006 Results article in https://doi.org/10.1038/sj.bjc.6603134 (added 26/08/2021)
Study Design
- Study Type
- Interventional
Eligibility Criteria
Inclusion Criteria
- •1. T4 N0-1 M0
- •2. Tumour length less than 10 cm
- •3. Upper tumour border 2 cm of upper oesophageal sphincter
- •4. Tumour must not extend more than 4 cm into the stomach
- •5. World Health Organisation (WHO) grade zero to two
- •6. Adequate haematological, renal, hepatic and pulmonal function
- •7. Adequate caloric- and/or fluid intake
Exclusion Criteria
- •1. Previous chemotherapy and or radiotherapy on mediastinum or upper abdomen
- •2. Myocardial Infarction (MI) within last six months
- •3. Ventricular arrhythmia or congestive heart failure
- •4. Second or third degree heart blocks
- •5. Pre-existing neurotoxicity more than grade one
- •6. Active infection
Investigators
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