Potentially Inappropriate Prescribing (PIP) in Long-Term Care (LTC) Patients: Validation of the 2014 STOPP-START and 2012 Beers Criteria in a LTC Population
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 275
- 试验地点
- 6
- 主要终点
- Validation of STOPP/START and Beers criteria by comparing their use in health administrative data and clinical data
研究概览
简要总结
The study objectives are: to validate the subsets of Screening Tool of Older People's Prescriptions (STOPP) and Screening Tool to Alert Right Treatment (START), or STOPP/START criteria, and Beers criteria applicable to HAD by comparing their performance when applied to clinical and HAD for the same patients, and, using clinical data, to compare the performance of the full STOPP/START and full Beers criteria with each other.
详细描述
Potentially inappropriate prescribing (PIP) is frequent, particularly in Long-Term Care (LTC) patients. Tools such as STOPP/START and Beers criteria were developed to identify PIP in clinical settings. Due to lack of clinical data in such databases, only a subset of these criteria are applicable to routinely collected health administrative data (HAD). This subset was shown to identify PIP in HAD with a frequency comparable to clinical studies using the full STOPP-START criteria. Nonetheless, the performance of subsets of STOPP/START and Beers criteria in HAD compared to clinical data from the same patients is unknown; furthermore, the performance of the updated 2014 STOPP-START and 2012 Beers criteria compared with one another is also unknown.
The overall aim of this study is to validate medication appropriateness criteria applicable to HAD by comparing their performance when applied to clinical data. The present study has two main and three secondary objectives (see Figure 1 for details):
A. Main objectives:
Objective 1: To validate subsets of the STOPP/START and Beers criteria defined by their applicability to HAD, by comparing their performance in detecting PIP when applied to HAD with that of the full set of criteria applied to clinical data for the same residents (with the clinical data providing the "gold standard").
Objective 2: To compare the detection rates of the full STOPP/START and full Beers criteria with one another when applied to clinical data.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 66 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •OHIP-eligible resident aged 66 and over at the time of admission to long-term care in Ottawa
- •Newly admitted to LTC or convalescent care at the participating care facilities
- •Consent to participate
排除标准
- •Residents will be excluded if they decline to participate in the study.
- •Residents will be excluded if they do not have a valid Ontario Health Insurance Plan (OHIP) number.
- •Residents residing in Ontario whose health care is covered through other plans, and are therefore not captured through ICES data, such as First Nations people living on reserve, members of the Armed Forces, and refugee claimants, will also be excluded.
- •A resident will also be excluded if he or she has no prescribed medications.
结局指标
主要结局
Validation of STOPP/START and Beers criteria by comparing their use in health administrative data and clinical data
时间窗: Participants will be observed retrospectively from Admission to Long Term Care facility to one year prior to admission to LTC
To validate subsets of the STOPP/START and Beers criteria defined by their applicability to HAD, by comparing their performance in detecting PIP when applied to HAD with that of the full set of criteria applied to clinical data for the same residents (with the clinical data providing the "gold standard").
Comparison of STOPP/START and Beers criteria
时间窗: Participants will be observed retrospectively from Admission to Long Term Care facility to one year prior to admission to LTC
To compare the detection rates of the full STOPP/START and full Beers criteria with one another when applied to clinical data.
次要结局
- Assessing STOPP/START and Beers criteria subset Performance in health administrative data versus full criteria used in clinical data(Participants will be observed retrospectively from Admission to Long Term Care facility to one year prior to admission to LTC)
- Assessing STOPP/START and Beers subset criteria performance in health administrative data when compared to clinical data for same resident(Participants will be observed retrospectively from Admission to Long Term Care facility to one year prior to admission to LTC)
- Comparison of performance of subset of STOPP/START with Beers criteria in health administrative data(Participants will be observed retrospectively from Admission to Long Term Care facility to one year prior to admission to LTC)
研究者
Lise Bjerre
Principal Investigator
Bruyere Research Institute