Clinical Correlation Between Facial Demodicosis and Ocular Demodicosis
试验速览
- 阶段
- 不适用
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Quantitative tests of facial and ocular demodicosis
研究概览
简要总结
To understand the association between facial demodicosis and ocular demodicosis, we plan to enroll patients with facial demodicosis, ocular demodicosis, or both, in order to analyze their clinical presentations, the density of Demodex infestation over facial skin and eyelashes, and possible risk factors of the two diagnoses.
详细描述
Although facial demodicosis and ocular demodicosis are described in a variety of clinical presentations, the association between the two diagnoses is not clearly identified.
Clinically, we plan to enroll 120 patients with facial demodicosis, ocular demodicosis. We will obtain their basic information, medical history, medication, and lifestyle. We will evaluate their clinical features. We will also perform quantitative tests including direct microscopic examination and cilia epilation test:
- Direct microscopic examination: On glabella and bilateral cheeks, follicular contents in the 1-cm × 1-cm area will be squeezed out. The contents are transferred onto a glass slide, covered with mineral oil and a cover slide, and examined under the microscope.
- Epilation: Four (4) non-adjacent cilia will be pulled from each upper eyelid and examined under the microscope. The total Demodex counts are recorded.
We will analyze the clinical presentations, the density of Demodex infestation, and possible risk factors of the two diagnoses.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient with a diagnosis of facial demodicosis or ocular demodicosis.
- •A. Facial demodicosis defined as both 1 and 2:
- •Clinical presentation of facial skin matches any of the followings:
- •Pityriasis folliculorum.
- •Papulopustular lesion.
- •Demodex infestation detected by direct microscopic examination ≥ 5 mites/cm
- •B. Ocular demodicosis defined as both 3 and 4:
- •Clinical presentation of ocular region matches any of the followings:
- •Chronic blepharitis.
- •Eyelash abnormalities: trichiasis, distichiasis, madarosis.
- •Meibomian gland dysfunction.
- •Recurrent chalazion.
- •Ocular rosacea.
- •Demodex infestation detected by cilia epilation test ≥ 1 mite/eyelid.
排除标准
- •Usage of oral Ivermectin, topical Ivermectin or topical tea tree oil in the past 1 month.
- •Patient who cannot tolerate direct microscopic examination or cilia epilation test.
结局指标
主要结局
Quantitative tests of facial and ocular demodicosis
时间窗: On initial evaluation
Association between the results of direct microscopic examination and cilia epilation test
次要结局
- Clinical features and quantitative tests of ocular demodicosis(On initial evaluation)
- Clinical features and quantitative tests of facial demodicosis(On initial evaluation)