KETOR: Effects of Peri Operative Administration of Ketamine on Long Term Post Thoracotomy Pain

Phase 3

Completed

• Conditions: Thoracotomy; Pain; Neuralgia; Ketamine; Chronic Post Thoracotomy Pain

• Registration Number: NCT00224588
• Lead Sponsor: Assistance Publique - Hôpitaux de Paris

Brief Summary

We assessed the effects of the N Methyl aspartate receptor antagonist Ketamine on long-term post thoracotomy pain. We hypothesized that ketamine could prevent supersensitization of the central nervous system involved in this chronic neuropathic pain.

Detailed Description

In this clinical, randomized prospective study, peri operative administration of ketamine was compared to placebo on long term post thoracotomy pain after a 2 months follow up period.

Study Timeline

• Study Start: 2003-01
• Study Completion: 2005-05
• Status Verified: 2005-09
• Study First Submitted: 2005-09-16
• Study First Submitted QC: 2005-09-16
• Study First Posted: 2005-09-23
• Last Update Submitted: 2006-04-12
• Last Update Posted: 2006-04-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Patients eligible for thoracotomy or pneumectomy

Read More

Exclusion Criteria

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Long term (2 months) post thoracotomy pain was assessed using a french equivalent of the Mc Gill Pain score and pain area measurements in both groups

Secondary Outcome Measures

Name	Time	Method
Analogic pain scores at rest and after coughing

Trial Locations

Locations (1)

Georges Pompidou European Hospital; 🇫🇷 Paris, Ile de France, France