Microcirculation and Inflammatory Markers in Patients With Resistant, Stages 1/2 Hypertension and Normal Blood Pressure
- Conditions
- High Blood Pressure
- Registration Number
- NCT02759276
- Lead Sponsor
- Daniel Alexandre Bottino
- Brief Summary
Nailfold videocapillaroscopy (NVC), Venous occlusion Plethysmography (VOP) and inflammatory biomarkers have been used to study endothelial function in patients with resistant hypertension, stages 1 and 2 hypertension and normotensive. This was a cross-sectional study.
- Detailed Description
Microcirculation determines peripheral resistance contributing to increased blood pressure. The nailfold videocapillaroscopy (NVC), Venous occlusion Plethysmography (VOP) and biomarkers can be used to evaluate the microcirculation in arterial hypertension (AH). The objective of this study is to analyze the behavior of serum inflammatory markers and study the microcirculation by nailfold videocapillaroscopy (NVC) and Venous Occlusion Plethysmography in patients with resistant hypertension (RH), with stages 1 and 2 hypertension (MMH ) and normotensive (CG). A cross-sectional study with 75 patients has been performed: 25 with resistant hypertension (RH), 25 with stages 1 and 2 hypertension (MMH) and 25 normotensive (CG). All underwent anamnesis, dosage serum markers and conducting NVC, VOP. Hypertensive patients without statin use and with controlled or uncontrolled blood pressure were also analyzed. For the statistical analysis were used: Kruskal -Wallis ANOVA, Dunn test and ANCOVA for correction of confusion factors such as age and BMI.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 75
- Clinical diagnosis of controlled High Blood Pressure stages 1 and 2 (blood pressure levels from 140/90 mmHg to 179/109 mmHg) .
- Resistant Hypertension (uncontrolled hypertension, with values ≥140/90 mmHg, using three or more antihypertensive drugs of different classes, including a diuretic, or controlled hypertension with four or more drugs).
- Normal Blood Pressure.
- Diabetes Mellitus, Types 1 or 2.
- Heart Failure.
- Myocardial infarction or stroke with less than three months of the event.
- Chronic kidney disease.
- Use of hormonal or non-hormonal anti-inflammatory drugs.
- Recent trauma (less than three months).
- Autoimmune diseases.
- Infectious processes in activity.
- Neoplasia.
- Aspirin use (anti-inflammatory dose).
- Obesity grade III (Body Mass Index>40 kg/m2).
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Blood Pressure (mmHg) 1 day Hemodynamic Variable
- Secondary Outcome Measures
Name Time Method Functional Capillary Density (FCD, number capillaries/mm2 ) 1 day Microcirculatory variable from Nailfold Videocapillaroscopy
Apical Capillary Diameter (micrometer) 1 day Microcirculatory variable from Nailfold Videocapillaroscopy
Afferent Capillary Diameter (micrometer) 1 day Microcirculatory variable from Nailfold Videocapillaroscopy
Efferent Capillary Diameter (micrometer) 1 day Microcirculatory variable from Nailfold Videocapillaroscopy
Maximal Forearm Blood Flow after sublingual nitroglycerine 1 day Vascular Reactivity Variables from Venous Occlusion Plethysmography
Intercellular Adhesion Molecule (ICAM, ng/dl) up to 2 weeks Inflammatory Biomarker
Time to reach Maximum Red Blood Cell Velocity (s) 1 day Microcirculatory variable from Nailfold Videocapillaroscopy
Maximal Forearm Blood Flow during reactive Hyperemia 1 day Vascular Reactivity Variables from Venous Occlusion Plethysmography
Endothelin (pg/dl) up to 2 weeks Inflammatory Biomarker
Waist circumference (cm) 1 day Anthropometrical Variable
Hip circumference (cm) 1 day Anthropometrical Variable
Vascular Cell Adhesion Molecule (VCAM, ng/dl) up to 2 weeks Inflammatory Biomarker
Adiponectin (ng/dl) up to 2 weeks Inflammatory Biomarker
C Reactive Protein (CRP, mg/dl) up to 2 weeks Inflammatory Biomarker
Red Blood Cell Velocity (mm/s) 1 day Microcirculatory variable from Nailfold Videocapillaroscopy
Maximum Red Blood Cell Velocity (mm/s) 1 day Microcirculatory variable from Nailfold Videocapillaroscopy
Body Mass Index (Kg/m2) 1 day Anthropometrical Variable
Waist to Hip Ratio 1 day Anthropometrical Variable