Markers of Oxidative Stress in a Early Week Miscarriage: Ischemia of Modified Albumin
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 180
- 试验地点
- 1
- 主要终点
- first trimester pregnant women
研究概览
简要总结
The finding that ischemia-modified albumin (IMA) is increased in pre-eclamptic pregnancy suggests a role for IMA as a potential biomarker for abnormal placental development related to miscarriage.This study was undertaken to evaluate IMA levels in women with recurrent pregnancy loss (RPL).
详细描述
Ischemia-modified albumin (IMA) measured by the albumin cobalt binding test is a relatively new biomarker in the identification of myocardial ischemia. Experimental studies have shown that pregnancies normally develop in a relatively hypoxic intrauterine environment, and the subsequent reperfusion and oxidative stress is important for physiological trophoblast development. The finding that maternal serum IMA levels are raised so early in pregnancy provides further support for IMA as a potential marker for abnormal placental development that may be related to early pregnancy loss. In this study, we aimed to evaluate maternal circulating IMA levels in women with RPL by comparing them with healthy controls.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •first trimester pregnancy
- •absence of fetal cardiac activity
- •absence of fetal pole
- •history of two or more unexplained first trimester miscarriages
- •no live births
- •apparently healthy women attending for antenatal care in the first trimester with at least one previous uneventful natural pregnancy
排除标准
- •pre-existing diabetes or vascular disease were excluded
- •diagnosis of chromosomal, anatomic, endocrinologic and autoimmunologic etiology of recurrent pregnancy loss
- •Women with multiple pregnancy
- •any major or minor fetal anomaly
- •current smokers
结局指标
主要结局
first trimester pregnant women
时间窗: under 14 w gestation
first trimester pregnancy with absence of fetal cardiac activity or absence of fetal pole on ultrasonographic examination Patients with a history of two or more unexplained first trimester miscarriages and no live births were included in the study.
次要结局
未报告次要终点
研究者
Hediye Dagdeviren
md
Bakirkoy Dr. Sadi Konuk Research and Training Hospital