Intrarenal T cells & chronic kidney graft rejection; the ITHACA study

Recruiting

• Conditions: anti-donor immunity; orgaantransplantatie; chronic kidney allograft rejection

• Registration Number: NL-OMON52370
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 100

Inclusion Criteria

-18 years and older
-able to give informed consent
-clinical diagnosis of chronic rejection for which a renal biopsy is indicated
for confirmation

Exclusion Criteria

-known extra risk for bleeding (e.g. clotting disorder or medication)

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameters will be the number and characterization of intrarenal<br /><br>T cells in cases of chronic kidney allograft rejection. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Intrarenal T cells isolated from cases with chronic rejection will be compared<br /><br>to those isolated from individuals with chronic interstitial fibrosis without<br /><br>evidence for rejection.</p><br>