The Effects of Protein Supplementation in Females and Males Following Acute Eccentric Exercise
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 90
- 试验地点
- 2
- 主要终点
- Concentration of Creatine Kinase at baseline
研究概览
简要总结
Examine the impact of the protein supplements leucine, HMB and BCAA on muscle recovery and inflammatory response following acute exercise.
详细描述
Participants, both females and males, will perform an acute bout of exercise. A bout of exercise that will involve multiple drop jumps. Prior to and post exercise, functional outputs will be measured and blood will be collected to quantify the inflammatory response. The protocol will involve attending the laboratory on 6 occasions over a two week period to complete the above measures.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Health recreationally active males and females.
排除标准
- •Asthma sufferers
- •People with kidney disease
- •People partaking in lower limb strength training
- •People suffering DOMS in the past 6 months
- •People already taking dietary supplements, other NSAIDs, or for example aspirin, alcohol, warfarin, phenytoin, methotrexate, lithium, diuretics, cyclosporine.
- •People with bone or soft tissue injury within last 12 months
- •People with gastric problems
- •People with hypertension
- •People who have had history of heart failure
- •People with liver disease
- •People with connective tissue disorders
- •People with Crohn's disease
- •People with ulcerative colitis
- •People with peripheral arterial disease
- •People with cerebrovascular disease
- •Elderly population
- •People with allergies to NSAIDs, Omega- 3 fatty acids and BCAAs.
- •People with depression
- •People with bipolar disorder
- •People with diabetes
- •Females who are pregnant
- •People who have HIV / AIDS
结局指标
主要结局
Concentration of Creatine Kinase at baseline
时间窗: Baseline
Blood taken from either vein or finger will be analysed for creatine kinase, a marker of muscle damage.
Concentration of Creatine Kinase immediately after intervention.
时间窗: Immediately after intervention.
Blood taken from either vein or finger will be analysed for creatine kinase, a marker of muscle damage.
Concentration of Creatine Kinase at 48 hours after intervention.
时间窗: 48 hours after intervention.
Blood taken from either vein or finger will be analysed for creatine kinase, a marker of muscle damage.
Concentration of Creatine Kinase at 7 days after intervention.
时间窗: 7 days after intervention.
Blood taken from either vein or finger will be analysed for creatine kinase, a marker of muscle damage.
Number of Chair Rises at 24 hours after intervention.
时间窗: 24 hours after intervention.
Stand and sit on chair consecutively for 30 seconds with hands placed on hips.
Squat Jump height immediately after intervention.
时间窗: Immediately after intervention.
Hands placed on hips, feet shoulder width apart. Bend knees to approx 45 degrees hold for 3 seconds and jump maximally.
Range of motion at 24 hours after intervention.
时间窗: 24 hours after intervention.
Sit on chair, then flex and extend legs three times from 90 degrees position.
Range of motion at 7 days after intervention.
时间窗: 7 days after intervention.
Sit on chair, then flex and extend legs three times from 90 degrees position.
Concentration of Creatine Kinase at 14 days after intervention.
时间窗: 14 days after intervention.
Blood taken from either vein or finger will be analysed for creatine kinase, a marker of muscle damage.
Number of Chair Rises at baseline
时间窗: Baseline
Stand and sit on chair consecutively for 30 seconds with hands placed on hips.
Number of Chair Rises immediately after intervention.
时间窗: Immediately after intervention.
Stand and sit on chair consecutively for 30 seconds with hands placed on hips.
Range of motion at 14 days after intervention.
时间窗: 14 days after intervention.
Sit on chair, then flex and extend legs three times from 90 degrees position.
Inflammatory cytokines concentration at 24 hours after intervention.
时间窗: 24 hours after intervention.
Blood from vein will be analysed for 10 different cytokines. Different cytokines include interleukins 1 beta, 2, 3, 4, 7, 8, 10, 17 and tutor necrosis factor receptor 1.
Concentration of Creatine Kinase at 24 hours after intervention.
时间窗: 24 hours after intervention.
Blood taken from either vein or finger will be analysed for creatine kinase, a marker of muscle damage.
Number of Chair Rises at 48 hours after intervention.
时间窗: 48 hours after intervention.
Stand and sit on chair consecutively for 30 seconds with hands placed on hips.
Number of Chair Rises at 7 days after intervention.
时间窗: 7 days after intervention.
Stand and sit on chair consecutively for 30 seconds with hands placed on hips.
Number of Chair Rises at 14 days after intervention.
时间窗: 14 days after intervention.
Stand and sit on chair consecutively for 30 seconds with hands placed on hips.
Squat Jump height at baseline
时间窗: Baseline
Hands placed on hips, feet shoulder width apart. Bend knees to approx 45 degrees hold for 3 seconds and jump maximally.
Squat Jump height at 48 hours after intervention.
时间窗: 48 hours after intervention.
Hands placed on hips, feet shoulder width apart. Bend knees to approx 45 degrees hold for 3 seconds and jump maximally.
Squat Jump height at 24 hours after intervention.
时间窗: 24 hours after intervention.
Hands placed on hips, feet shoulder width apart. Bend knees to approx 45 degrees hold for 3 seconds and jump maximally.
Squat Jump height at 7 days after intervention.
时间窗: 7 days after intervention.
Hands placed on hips, feet shoulder width apart. Bend knees to approx 45 degrees hold for 3 seconds and jump maximally.
Concentration of Lactate from baseline to immediately after intervention.
时间窗: Baseline and immediately after intervention.
Blood drop from finger will be used to lactate.
Muscle Soreness
时间窗: Daily for 14 days.
Record soreness on visual analogue scale from 1-10 1 = low soreness, 10 = extreme soreness.
Squat Jump height at 14 days after intervention.
时间窗: 14 days after intervention.
Hands placed on hips, feet shoulder width apart. Bend knees to approx 45 degrees hold for 3 seconds and jump maximally.
Range of motion at baseline.
时间窗: Baseline
Sit on chair, then flex and extend legs three times from 90 degrees position.
Range of motion immediately after intervention.
时间窗: Immediately after intervention.
Sit on chair, then flex and extend legs three times from 90 degrees position.
Range of motion at 48 hours after intervention.
时间窗: 48 hours after intervention.
Sit on chair, then flex and extend legs three times from 90 degrees position.
Inflammatory cytokines concentration at 48 hours after intervention.
时间窗: 48 hours after intervention.
Blood from vein will be analysed for 10 different cytokines. Different cytokines include interleukins 1 beta, 2, 3, 4, 7, 8, 10, 17 and tutor necrosis factor receptor 1.
Inflammatory cytokines concentration at 7 days after intervention.
时间窗: 7 days after intervention.
Blood from vein will be analysed for 10 different cytokines. Different cytokines include interleukins 1 beta, 2, 3, 4, 7, 8, 10, 17 and tutor necrosis factor receptor 1.
Inflammatory cytokines concentration at baseline
时间窗: Baseline
Blood from vein will be analysed for 10 different cytokines. Different cytokines include interleukins 1 beta, 2, 3, 4, 7, 8, 10, 17 and tutor necrosis factor receptor 1.
次要结局
- Weighed food diaries.(Daily for 14 days.)