Adjunctive Transcranial Stimulation to Reduce Impulsivity in Opiate Use Disorder

Not Applicable

Completed

• Conditions: Opioid-use Disorder; Tobacco Use Disorder

• Registration Number: NCT05049460
• Lead Sponsor: Gopalkumar Rakesh

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-9-8
• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

Inclusion Criteria:<br><br> - Patients enrolled in the SMART Clinic at University of Kentucky<br><br> - 18-60 years of age<br><br> - Preferably right hand dominant<br><br> - Currently self-report smoking 10 of more cigarettes per day or a score of > 5 on the<br> Fagerstrom Test for Nicotine<br><br> - Willing and able to abstain from all drug use<br><br> - Exhaled breath on day of study CO < 10 ppm<br><br> - Stabilized on maintenance buprenorphine if having comorbid opioid use disorder<br><br> - Able to read and speak English<br><br> - Able to provide informed consent to participate.<br><br>Exclusion Criteria:<br><br> - Pregnant, nursing, or becoming pregnant during the study.<br><br> - History of traumatic brain injury or seizures which are contraindications for<br> transcranial magnetic stimulation (TMS).<br><br> - Increased risk of seizure for any reason, including prior diagnosis of epilepsy,<br> seizure disorder, increased intracranial pressure, or history of significant head<br> trauma with loss of consciousness for = 5 minutes which are all contraindications<br> for TMS.<br><br> - Presence of intracranial implants (e.g. aneurysms clips, shunts, stimulators,<br> cochlear implants, or electrodes), cardiac pacemakers, or vagus nerve stimulation<br> device which are all contraindications for magnetic resonance imaging.<br><br> - Neurological disorder including, but not limited to: space occupying brain lesion;<br> any history of seizures, history of cerebrovascular accident; fainting, cerebral<br> aneurysm, major neurocognitive disorder, Huntington chorea; multiple sclerosis which<br> are all contraindications for TMS.

Exclusion Criteria

Not provided

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Attentional bias for smoking stimuli;Attentional bias for smoking stimuli;Attentional bias for opioid stimuli;Attentional bias for opioid stimuli;Craving;Craving

Secondary Outcome Measures

Name	Time	Method
Functional connectivity changes;Functional connectivity changes