Sarcoidosis and Fatigue: Influence of successive cardiopulmonary exercise testing on fatigue, ACE, cytokine response and acitivity patter
Recruiting
- Conditions
- Morbus Besnier Boeck (Schaumann)Sarcoidosis1002766510038716
- Registration Number
- NL-OMON33379
- Lead Sponsor
- Rijnstate Ziekenhuis
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
Sarcoidosis
diagnosis confirmed within 1 year before inclusion
18 years and older
informed consent
see protocol section 4.2
Exclusion Criteria
corticosteroid use, cardiovasculair comorbidity
see protocol section 4.3
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Recuperative capacity: Outcome on two maximal exercise tests (bicycle<br /><br>ergometer): comparing results of cardiovascular, pulmonary and aerobic capacity<br /><br>on two successive days.<br /><br>Fatigue: State of fatigue (before and after exercise) will be evaluated by<br /><br>Visual Analogue Scales. Trend of fatigue (at the start of taking part in this<br /><br>study and after completing) will be measured with the CIS-20R-08-questionnaire.<br /><br>Measurements in serum: Level of ACE, including genotype of patients for ACE and<br /><br>levels of cytokines will be determined (IL-6 and TNF-a before and after<br /><br>exercise). </p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary objective is to find associations between exercise and patterns of<br /><br>sleep behaviour and acitivity, not only on basis of patient reports, but also<br /><br>objectified bij means of an accelerometer.</p><br>