Efficacy of Sulphadoxine-Pyrimethamine versus Dihydroartemisinin-Piperaquine for Intermittent Preventive Therapy of Pregnancy-associated Malaria
Not Applicable
- Conditions
- Malaria
- Registration Number
- PACTR201701001982152
- Lead Sponsor
- Babcock University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Female
- Target Recruitment
- 350
Inclusion Criteria
Pregnant women
¿18years old,
16-28weeks gestational age at enrollment,
living within the study vicinity
and willing to deliver at the study site facility,
had no anti-malarial,tetracycline or sulphonamide-derivative drugs within the preceding seven days,who give consent.
Exclusion Criteria
Pregnant women who do not meet the inclusion criteria,
HIV-positive women,
hypersensitivity to any of the study drugs.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method -Prevalence of placental malaria diagnosed histopathologically by parasite presence;-Incidence of maternal malaria infection by day 28 post-IPT diagnosed by clinical and parasitological methods
- Secondary Outcome Measures
Name Time Method Incidence of: maternal anemia,spontaneous miscarriage,preterm delivery,low birth weight,still birth,congenital anomalies,neonatal death;-Prevalence of resistance markers on molecular analysis;-Plasma drug concentration ;-Drug tolerability and incidence of adverse events