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Treatment of congenital toxoplasmosis with pyrimethamine/sulfadiazine

Phase 2
Recruiting
Conditions
Congenital toxoplasmosis
Registration Number
JPRN-jRCTs071180093
Lead Sponsor
Maruyama Haruhiko
Brief Summary

Not available

Detailed Description

Not available

Recruitment & Eligibility

Status
Recruiting
Sex
All
Target Recruitment
35
Inclusion Criteria

1. Confirmed toxoplasmosis fulfilling one of the followings
#1 Toxoplasma DNA detected in placenta or other tissues
#2 pathological identification of Toxoplasma
#3 anti-Toxoplasma IgM in cord blood or sera within 6 months after birth
#4 increase of anti-Toxoplasma IgG within 1 year after birth
#5 positive anti-Toxoplasma IgG after 12 months after birth
2. Suspected toxoplasmosis with all of the followings
#1 typical symptoms (e.g. intra-cranial calcification)
#2 positive anti-Toxoplasma IgG
#3 other congenital infections excluded

Exclusion Criteria

#1 HIV positive patients
#2 patients allergic to test compounds
#3 patients with megaloblastic anemia due to
folate deficiency
#4 No consent is given from the patient
him/herself nor a legally authorized
representative/guardian of the patient
#5 patients principal investigator judged
inappropriate

Study & Design

Study Type
Interventional
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Secondary Outcome Measures
NameTimeMethod
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