Minocycline in the treatment of Depressio
Phase 3
Completed
- Conditions
- Major depressive disorder.Major Depressive episode
- Registration Number
- IRCT201405271556N57
- Lead Sponsor
- Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
1-Confirmation of HIV infection by Western-blot test 2-receiving HAART medications 3- score lower than 20 in Hamilton Rating Scale for depression 4-Mild to moderate major depressive disorder based on DSM-V 5-consent for entering the trial
Exclusin criteria: 1-receving antidepressants, 2-ongoing addiction, 3-opportunistic infections during 45 days before entering the trial, 4-severe depression and suicidality, 6-death of loved ones during the last month, 7-active infection and fever, 8-cancer, 9-pregnancy, 10-alcohol dependence, 11-history of allergy to minocycline or other tetracyclines, 12- Cognitive disorders including dementia due to HIV
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Severity of depression. Timepoint: Baseline and weeks 1-3-6 after beginig of treatment. Method of measurement: by Hamiltion Depression Rating Scale 17-Item.
- Secondary Outcome Measures
Name Time Method