This is an interventional study to assess and compare Semaphorin 4D, Peptidylarginine Deiminase 2 and Matrix Metalloproteinase-8 in Gingival crevicular fluid levels before and after Non-surgical periodontal therapy in periodontally healthy, Severe periodontitis Smoker and non-smoker patients.
- Conditions
- Health Condition 1: K053- Chronic periodontitis
- Registration Number
- CTRI/2020/03/024346
- Lead Sponsor
- Dr Aishwarya Ikhar
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Group I: Periodontally healthy patients.
Group II: Non-Smoker patients with untreated stage III periodontitis, with PPD more than equal to 5 mm and CAL more than equal to 4mm, BOP at >50% of sites (full mouth) and radiographic evidence of interproximal bone loss.
Group III: Smoker patients with untreated stage III periodontitis, with PPD more than equal to 5 mm and CAL more than equal to 4mm, BOP at >50% of sites (full mouth) and radiographic evidence of interproximal bone loss.
1.Patients who had received periodontal treatment within the last 6 months.
2.Patients with any systemic diseases.
3.Patients who had or are on immunosuppressive chemotherapy.
4.Use of antibiotics within the last 6 months and anti-inflammatory drugs within the last 3 months.
5.Pregnant and lactating females.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method