Measuring oxygen saturation in the retina with a modified fundus camera

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 12

Inclusion Criteria

• You are healthy (as defined in the criteria below). • You are between 18 and
50 years old. • You don't smoke. • You are not pregnant. • You have a BMI
between 18 and 25 kg/m2. BMI formula: weight in kilograms / (height in meters *
height in meters). • You do not drink alcohol on the evening before the start
of the test day. • You have not used any drugs in the past 3 months. • You are
prepared to undergo a medical examination, consisting of a short physical
examination, completing a few questionnaires and a short ECG. • You have no
cardiovascular disorders. • You are not familiar with psychiatric and/or
neurological disorders. • You do not have chronic anemia. • You are not
claustrophobic and able to spend an hour in a confined space. • You have not
donated blood in the past 72 hours • You are not overly sensitive to
airsickness (a form of motion sickness, where you become ill from a flight). •
You have not been at altitude (>2000m) for more than a week in the past 3
months. • You accept that the collected data will be stored and processed in
encrypted form, archived for at least 10 years and possibly published.

Exclusion Criteria

none, other than not fulfilling the inclusion criteria

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary outcome measure is the SpO2 in the retina at different simulated<br /><br>heights. The data is collected with the adapted fundus camera. The criterion<br /><br>validity of the data is assessed by comparing the data with data measured with<br /><br>a reference method (finger NIRS, WristOx 3150 with 8000SM-WO2 soft sensor,<br /><br>Nonin Medical Inc, Plymouth, USA).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>A secondary outcome measure is heart rate (beats per minute) measured in the<br /><br>retina. The twilight lighting conditions may make it possible to distill the<br /><br>heart rate from data measured with the modified fundus camera. The validity of<br /><br>the data is again assessed by comparing it with data measured with the above<br /><br>reference method (finger NIRS, WristOx 3150 with 8000SM-WO2 soft sensor, Nonin<br /><br>Medical Inc, Plymouth, USA).</p><br>