Testicular Function and Semen Quality in Male Childhood and Adolescent Cancer Survivors

Recruiting

• Conditions: Cancer, Treatment-Related; Late Effect; Semen Analysis
• Interventions: Other: Hormonal profile; Other: Semen analysis; Other: Questionnaire

• Registration Number: NCT06587477
• Lead Sponsor: The University of Hong Kong

Brief Summary

Cancer treatment can affect the testicular function, including sperm and hormonal functions. The aim of this study is to assess the testicular function and semen quality in young men who recover from childhood and adolescent cancer in Hong Kong. This can provide more information for pre-treatment counselling as well as improve post treatment survivorship care. The testicular function will be compared to aged-matched controls from men attending the Family Planning Association for premarital check-up.

Detailed Description

This is a cohort observational study. The target population for the trial will be men who have received chemotherapy and/ or radiotherapy for cancer diagnosed when they were \< 18 years old, currently \> 18 years old to 50 years old and cancer in remission for at least 2 years. The testicular function, including sperm and hormonal functions, will be compared with aged-matched controls from men attending the Family Planning Association for premarital check-up.

Study Timeline

• Study Start: 2023-01-16
• Status Verified: 2024-05
• Study First Submitted: 2024-05-13
• Study First Submitted QC: 2024-09-06
• Last Update Submitted: 2024-09-06
• Study First Posted: 2024-09-09
• Last Update Posted: 2024-09-09
• Primary Completion: 2027-12-31
• Study Completion: 2028-06-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: Male
• Target Recruitment: 200

Inclusion Criteria

• Men who have received chemotherapy and/ or radiotherapy for cancer diagnosed when they were < 18 years old.
• > 18 years old to 50 years old
• Cancer in remission for at least 2 years

Exclusion Criteria

• Unable to ejaculate by masturbation to provide semen samples
• Cryptorchidism, testicular cancer, history of vasectomy
• On testosterone replacement therapy
• Refusal to join the study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Male childhood and adolescent cancer survivors	Questionnaire	Male childhood and adolescent cancer survivors
Controls	Hormonal profile	Aged-matched controls from men attending the Family Planning Association for premarital check-up
Controls	Semen analysis	Aged-matched controls from men attending the Family Planning Association for premarital check-up
Controls	Questionnaire	Aged-matched controls from men attending the Family Planning Association for premarital check-up
Male childhood and adolescent cancer survivors	Hormonal profile	Male childhood and adolescent cancer survivors
Male childhood and adolescent cancer survivors	Semen analysis	Male childhood and adolescent cancer survivors

Primary Outcome Measures

Name	Time	Method
Sperm concentration	up to 3 months	Sperm concentration

Secondary Outcome Measures

Name	Time	Method
Semen parameters	up to 3 months	Based on the WHO criteria

Trial Locations

Locations (1)

Queen Mary Hospital; 🇨🇳 Hong Kong, China