Effect of Lidocaine 1% and 2% in the Endotracheal Tube Cuff on Postoperative Sore Throat and Cough
Overview
- Phase
- Not Applicable
- Intervention
- cuff inflation with air
- Conditions
- Postoperative Sore Throat
- Sponsor
- Ogarite Habib
- Enrollment
- 150
- Primary Endpoint
- Sore throat intensity 2
- Last Updated
- 7 years ago
Overview
Brief Summary
Comparing the effect of different methods of endotracheal tube cuff inflation on the occurrence of a postoperative sore throat and cough (Air vs Lidocaine 1% vs Lidocaine 2%).
Detailed Description
Eligible patients undergoing general anesthesia will be randomized and assigned to three groups: Group A: Endotracheal tube cuff inflation with air Group B: Endotracheal tube cuff inflation with Lidocaine 1% Group C: Endotracheal tube cuff inflation with Lidocaine 2% The induction of anesthesia will be made following a preoxygenation with a facial mask with 100% Oxygen. It consists on the intravenous injection of Sufentanil 5 mcg or Fentanyl 50mcg, Lidocaine 1mg/Kg, Propofol 2.5mg/kg, Rocuronium 0.6mg/kg or Cisatracurium 0.15mg/kg. Maintenance of anesthesia will be done by sevoflurane + nitrous oxide, and reinjections of morphinomimetics and curare will be made as needed (the total doses will be noted at the end of the intervention). The intubation is made by a N° 7.5 tube in men and a N° 7 tube in women. Cuff inflation will be done upon placement of the endotracheal tube. The cuff's pressure will be monitored at several intervals of the intervention and kept \< or = 20 centimeter of water (cmH2O). The volume of lidocaine used will never exceed 5 mg / kg for the patient to be protected from the local toxicity of the local anesthetic in case of accidental rupture of the balloon. All patients will receive Paracetamol every 6 hours for the first 24 hours after the end of surgery.
Investigators
Ogarite Habib
Principal Investigator
Saint-Joseph University
Eligibility Criteria
Inclusion Criteria
- •Patients over 18 years old
- •American Society of Anesthesiologists classification (ASA) category 1 or 2
- •High pressure, low volume endotracheal tube - (Lo-pro)
Exclusion Criteria
- •Ear nose and throat and cranial surgery
- •Ear nose and throat pathologies
- •Asthma and bronchial hyperreactivity
- •Chronic cough
- •Cognitive disorders
- •Swallowing disorders
- •Corticotherapy during the last week
- •Allergy to lidocaine
- •Urgent surgery
- •Nasogastric, oro-gastric
Arms & Interventions
Air
Endotracheal tube cuff inflation with air
Intervention: cuff inflation with air
Air
Endotracheal tube cuff inflation with air
Intervention: Induction of anesthesia
Air
Endotracheal tube cuff inflation with air
Intervention: Maintenance of anesthesia
Air
Endotracheal tube cuff inflation with air
Intervention: Endotracheal intubation
Air
Endotracheal tube cuff inflation with air
Intervention: Systematic post-operative analgesia
Lidocaine 1%
Endotracheal tube cuff inflation with Lidocaine 1%
Intervention: cuff inflation with lidocaine 1%
Lidocaine 1%
Endotracheal tube cuff inflation with Lidocaine 1%
Intervention: Induction of anesthesia
Lidocaine 1%
Endotracheal tube cuff inflation with Lidocaine 1%
Intervention: Maintenance of anesthesia
Lidocaine 1%
Endotracheal tube cuff inflation with Lidocaine 1%
Intervention: Endotracheal intubation
Lidocaine 1%
Endotracheal tube cuff inflation with Lidocaine 1%
Intervention: Systematic post-operative analgesia
Lidocaine 2%
Endotracheal tube cuff inflation with Lidocaine 2%
Intervention: cuff inflation with lidocaine 2%
Lidocaine 2%
Endotracheal tube cuff inflation with Lidocaine 2%
Intervention: Induction of anesthesia
Lidocaine 2%
Endotracheal tube cuff inflation with Lidocaine 2%
Intervention: Maintenance of anesthesia
Lidocaine 2%
Endotracheal tube cuff inflation with Lidocaine 2%
Intervention: Endotracheal intubation
Lidocaine 2%
Endotracheal tube cuff inflation with Lidocaine 2%
Intervention: Systematic post-operative analgesia
Outcomes
Primary Outcomes
Sore throat intensity 2
Time Frame: at 2 hours after extubation
Throat pain evaluation using the visual analog scale of pain (range from 0 cm (no pain) to 10 cm (very intense pain))
Cough intensity 2
Time Frame: at 2 hours after extubation
Cough intensity evaluation using the visual analog scale of cough (range from 0 cm (no cough) to 10 cm (very severe cough))
Cough intensity 6
Time Frame: at 6 hours after extubation
Cough intensity evaluation using the visual analog scale of cough (range from 0 cm (no cough) to 10 cm (very severe cough))
Cough intensity 24
Time Frame: at 24 hours after extubation
Cough intensity evaluation using the visual analog scale of cough (range from 0 cm (no cough) to 10 cm (very severe cough))
Cough intensity 0
Time Frame: hour 0 after extubation
Cough intensity evaluation using the visual analog scale of cough (range from 0 cm (no cough) to 10 cm (very severe cough))
Sore throat intensity 0
Time Frame: hour 0 after extubation
Throat pain evaluation using the visual analog scale of pain (range from 0 cm (no pain) to 10 cm (very intense pain))
Sore throat intensity 24
Time Frame: at 24 hours after extubation
Throat pain evaluation using the visual analog scale of pain (range: from 0 cm (no pain) to 10 cm (very intense pain))
Sore throat intensity 6
Time Frame: at 6 hours after extubation
Throat pain evaluation using the visual analog scale of pain (range from 0 cm (no pain) to 10 cm (very intense pain))