Effect of Passive Smoking on Platelet Function and Endothelial Function

Not Applicable

Completed

• Conditions: Endothelial Function; Platelet Aggregation

• Registration Number: NCT00923988
• Lead Sponsor: Kantonsspital Graubünden

Brief Summary

Passive smoking is associated with an increased risk for cardiovascular events. However, the exact mechanisms by which passive smoking affects cardiovascular health are not entirely understood. In the present study, the researchers investigate the effects of short-term exposure to secondhand smoke on platelet function and peripheral microvascular endothelial function in healthy individuals. For this purpose, platelet function and endothelial function are measured before and after a 1-hour exposure to secondhand smoke in a concentration that is encountered in bars and restaurants without smoke-free policies. The researchers' hypothesis is that short-term exposure leads to platelet activation and impairment of endothelial function.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-06
• Study First Submitted: 2009-06-17
• Study First Submitted QC: 2009-06-17
• Study First Posted: 2009-06-18
• Status Verified: 2009-08
• Primary Completion: 2009-08
• Study Completion: 2009-08
• Last Update Submitted: 2009-08-10
• Last Update Posted: 2009-08-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• healthy individuals
• nonsmokers
• no regular medication (in particular no drugs affecting platelet function or vascular function)

Exclusion Criteria

• exposition to secondhand smoke within 1 week before inclusion
• use of drugs affecting platelet function or vascular function within 1 week before study inclusion

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Change in platelet aggregation and/or endothelial function	12-24 hours

Trial Locations

Locations (1)

Kantonsspital Graubuenden; 🇨🇭 Chur, Switzerland