The Effect of L-arginine in the treatment of Sickle Cell Anemia

Not Applicable

• Conditions: sickle cell anemia; D57.1; C15.378.071.141.150.150

• Registration Number: RBR-2t56nz
• Lead Sponsor: niversidade Federal do Ceará

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-10-24
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Data analysis completed
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Adult patients volunteers between 18 and 80 years with sickle cell anemia; both genders; in use of hydroxiurea from 500mg per day; baseline

Exclusion Criteria

Patients who do not have sickle cell anemia; Patients who refuse to participate in the study not signing the ethic term; those who have had transfusional therapy in the last three months; patients using iron chelator and antioxidant vitamins; patients smokers and drinkers; pregnant or with diabetes mellitus or with some picture of renal or hepatic insufficiency

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Increased nitrite levels in the 4-month clinical trial using the ELISA kit for the amount of plasma nitrite in the patient's plasma in grams per liter;There was a significant increase analyzed by p value of 0.004 after 4 months treatment<br>There was a significant increase analyzed by the p-value of 0.004 after the 4-month treatment mentioned above<br>The nitrite levels before treatment were 38.27 g per L, standard deviation of 17.27, to 34.45 g per L, standard deviation of 11.25 after four months of treatment<br>The study group obtained nitrite levels before starting treatment of 36.55 g per L, with a standard deviation of 20.23 to 48.64, with a standard deviation of 20.63 after four months of treatment

Secondary Outcome Measures

Name	Time	Method
Reduction of pain frequency during treatment, from pain once a day to once a week, analyzed through each patient's questionnaire;The patients in the study group reduced that pain frequency with p of 0.027 after 4 months treatment