TCTR20220503004Unknown4 期
The efficacy of combination therapy of metoclopramide and prucalopride versus placebo in reducing gastric residual volume in critically ill patients: A randomized controlled trial
Faculty of Medicine, Prince of Songkla University0 个研究点目标入组 62 人开始时间: 2022年5月3日最近更新:
适应症
试验速览
- 阶段
- 4 期
- 发起方
- 入组人数
- 62
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 Years 至 85 Years（—）
- 性别
- All
入选标准
- •1. Patients in medical intensive care units and medical respiratory care units
- •2. Feeding intolerance, defined as GRV of 250 ml or more
- •3. Expected to be on tube feeding for at least 5 days (by their primary doctors)
排除标准
- •1. Receiving prokinetic drugs within the previous 24 hours
- •2. History of allergy to prucalopride or metoclopramide
- •3. Gastrointestinal bleeding, obstruction, or perforation
- •4. Hemodynamic instability at the time of enteral tube feeding initiation, defined as a mean arterial pressure of less than 50 mmHg or escalating doses of vasopressor or inotropic agents required to maintain a MAP value of more than 50 mmHg within 24 hours
- •5. Undergone major gastrointestinal surgery (laparotomy with part of gastrointestinal tract removed or repaired) within the previous 2 weeks
- •6. Severe inflammatory conditions of the gastrointestinal tract such as Crohn's disease, ulcerative colitis, and toxic megacolon, or preexisting chronic diarrheal diseases
- •7. Underlying of known pheochromocytoma
- •8. QT prolongation on 12-lead ECG, defined by QTc of more than 440 ms in male and 460 ms in female
- •9. History of extrapyramidal symptoms
- •10. Presence of clinical refeeding syndrome
- •11. On gastrostomy tube
- •12. Pregnancy
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