Effects of Ten-Weeks Progressive Resistance Training on Neuromuscular Performance, Mobility, Heart Rate Variability and Sleep Quality in Persons With Multiple Sclerosis
概览
- 阶段
- 不适用
- 干预措施
- 未指定
- 疾病 / 适应症
- Multiple Sclerosis
- 发起方
- Universidad Católica San Antonio de Murcia
- 入组人数
- 36
- 试验地点
- 1
- 主要终点
- Rate of Force Development
- 状态
- 已完成
- 最后更新
- 5年前
概览
简要总结
Multiple Sclerosis (ME) is a degenerative, inflammatory and autoimmune demyelinating disease of the central nervous system, characterized by demyelination due to inflammation and degeneration of the myelin sheaths enveloping nerves of the eye, periventricular grey matter, brain, spinal cord and brainstem. The symptoms associated with MS include symptomatic fatigue, muscle weakness, ataxia, mobility and balance problems or cognitive problems. Strength training has been shown to improve strength and mobility in persons with MS.
详细描述
Multiple Sclerosis (ME) is a degenerative, inflammatory and autoimmune demyelinating disease of the central nervous system, characterized by demyelination due to inflammation and degeneration of the myelin sheaths enveloping nerves of the eye, periventricular grey matter, brain, spinal cord and brainstem. The symptoms associated with MS include symptomatic fatigue, muscle weakness, ataxia, mobility and balance problems or cognitive problems. Resistance training has been shown to improve strength, sleep quality and mobility in persons with MS.
研究者
Jacobo Á. Rubio
Principal Investigator
Universidad Católica San Antonio de Murcia
入排标准
入选标准
- •mild or moderate disability with clinical mild spastic-ataxic gait disorder.
- •stable phase of the disease.
排除标准
- •Expanded Disability Status Scale (EDSS) \<
- •relapsing disease within the preceding 12 months.
- •corticosteroid treatment within the last months before study inclusion.
结局指标
主要结局
Rate of Force Development
时间窗: After 10 weeks
Rate of force development in knee extension
Spasticity
时间窗: After 10 weeks
Pendulum test
Maximal Voluntary Isometric Contraction of Knee Extension
时间窗: After 10 weeks
the maximum force (N) that can be produced voluntarily by the knee extension muscles during an isometric contraction is measured. The leg of the participant is fixed to an isokinetic device, and the participant makes a 5-second attempt, developing all the strength he or she can.
Central Activation Ratio
时间窗: After 10 weeks
The central activation ratio (CAR) was determined using superimposed electrical stimulation during maximum voluntary contractions
次要结局
- Walking speed(After 10 weeks)
- Static Balance(After 10 weeks)
- Functional capacity(After 10 weeks)
- Heart Rate Variability(After 10 weeks)
- Sleep Quality(After 10 weeks)