Investigation of treatment expectancy in patients with atopic dermatitis undergoing a modern system therapy

Recruiting

Conditions: L20
Atopic dermatitis

Registration Number: DRKS00032191

Lead Sponsor: niversitätsklinikum Essen (AöR), Klinik für Dermatologie, Venerologie und Allergologie

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 100

Inclusion Criteria

Patients with atopic dermatitis and indication for initiation of systemic therapy.
- Women of childbearing potential with contraception (according to the Standard of Care)

Exclusion Criteria

- Pregnancy and breast-feeding; lack of willingness to use effective contraception.
- Insufficient ability to communicate in the German language or lack of understanding of the German language; dementia or (functional) illiteracy.
- Lacking or absent capacity of the patient to give consent
- Presence of contraindications to systemic therapy with an IL-4 and IL-13 blocker or a JAK inhibitor.

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
- Subjective pror experiences, expectations as well as perception of warmth and competence at the beginning and during the course of therapy<br>- Correlation of recorded psychological factors and skin symptoms before and during therapy<br>- Correlation of recorded psychological factors and perceived treatment success<br>- Comparison of proinflammatory cytokines in blood serum (especially IL-4, IL-5, IL-13, IL-31) and serum cortisol before the start of therapy and 16 weeks after therapy initiation

Secondary Outcome Measures

Name	Time	Method
- Association of recorded psychological factors and therapy success with the level of proinflammatory cytokines and serum cortisol.<br>- Associations of psychological factors prior experience, expectancy, and perceptions of warmth and competence with each other<br>- Correlations of proinflammatory cytokine activity with plasma cortisol activity