The impact of treatment expectation on the effectiveness and tolerability of prophylaxis in migraine patients
- Conditions
- G43.0G43.1Migraine without aura [common migraine]Migraine with aura [classical migraine]
- Registration Number
- DRKS00022882
- Lead Sponsor
- Klinische NeurowissenschaftenUniversitätsklinikum EssenKlinik für Neurologie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 134
Inclusion Criteria
Patients with episodic or chronic migraine starting a new medical prophylaxis comprising amitriptyline, beta blockers, topiramate, valproic acid, magnesium, flunarizine or onabotulinumtoxinA (new prophylaxis or add on)
Exclusion Criteria
pregnancy or breast-feeding
missing language skills
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Development of headache days over the course of 6 months
- Secondary Outcome Measures
Name Time Method Development of migraine days, pain intensity, pain duration, quality of life, side effects, impairment related to headache, depression, anxiety and stress over a period of 6 months.<br><br>Differences between responders and non-responders.<br>Differences between patients with and without prior experiences with pharmacological prophylaxis.<br><br>Influence expectation (CEQ-expectancy) and genetic predispositions (COMT) on all endpoints will be investigated.