Effects of treatment expectation towards transcranial magnetic stimulation in major depressive disorder
- Conditions
- moderate depressive episode, severe depressive episode
- Registration Number
- DRKS00028017
- Lead Sponsor
- VR-Klinikum Essen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 60
o Age from 18 to 65 years
o moderate or severe depressive episode (according to Hamilton Rating Scale for Depression, HDRS)
o at least 2 unsuccessful antidepressant medication attempts in the history of the current episode
o Incapacitated persons and persons in official or judicial custody.
o Persons with consumptive diseases and/or in poor general condition
o No sufficient hearing or reading ability
o Contraindications for rTMS
presence of ferromagnetic material (e.g. cochlear implants) in the brain
Pregnancy
Cardiac pacemaker
Epilepsy
o previous rTMS treatment
o electroconvulsive therapy in the preceding 6 months
o relevant structural lesions on MRI: this excludes expected age-related changes such as mild cerebral microangiopathy in patients over 50 years of age or changes without expected relevance such as small arachnoid cyst
o Relevant comorbidities
Current substance abuse or dependence
Organic mental disorders
Dementia
Schizophrenia and schizoaffective disorder
Neurological disorders, e.g., multiple sclerosis, Parkinson's syndrome (excluding headache disorders)
Diseases that are associated with an inflammatory response and lead to permanently elevated inflammatory parameters
Severe internal diseases associated with a significantly reduced general condition
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Therapy success. Measurement: questionnaires.
- Secondary Outcome Measures
Name Time Method therapy success. Measurement: cognitive tests, MRI, blood sampes, salive samples