NCT01819883已完成不适用
Ectopic Lipid Deposition and Insulin Resistance in After Treatment of Acromegaly
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Change in Liver Fat
研究概览
简要总结
This study investigates fat distribution in people with acromegaly. The investigator is also investigating the change of fat distribution before and after treatment of acromegaly. The investigator will compare the results of people with acromegaly to the results of healthy volunteers.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Ages 18 - 75 yr (both groups)
- •Study subjects with active acromegaly
- •Healthy controls
排除标准
- •Serum creatinine or alanine aminotransferase (ALT) > 2 times the upper limit of normal, metastatic cancer.
- •Controls will be receiving no medications and have no chronic diseases, including cancer, hypertension or diabetes mellitus.
- •Contraindications to MRI imaging (both groups) like those with certain metal implants, surgical clips or pacemakers.
- •Pregnant women
结局指标
主要结局
Change in Liver Fat
时间窗: Baseline and 3-month follow-up visit
Change in intrahepatic fat after biochemical control of acromegaly
Change in Thigh Muscle Cross-sectional Area
时间窗: Baseline and 3-month follow-up visit
Change in thigh muscle cross-sectional area after biochemical control of acromegaly
次要结局
未报告次要终点
研究者
Karen Klahr Miller, MD
Assistant Physician in Medicine
Massachusetts General Hospital
研究点 (1)
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