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Clinical Trials/NCT01644942
NCT01644942CompletedNot Applicable

Identification in Obese Patients of the Mechanisms Involved in Intramuscular Lipid Accumulation.

University Hospital, Montpellier2 sites in 1 country33 target enrollmentStarted: May 2008Last updated:
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Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Enrollment
33
Locations
2
Primary Endpoint
lipid accumulation in skeletal muscle
Study OverviewStudy DesignEligibility CriteriaOutcomesInvestigatorsSitesRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

The study aims to determine in obese patients the implication of intramuscular lipid accumulation in relation with insulin resistance and defect in lipid oxidation.

Detailed Description

Obese insulin sensitive and obese insulin resistant patients undergo a glucose tolerance test, indirect calorimetry during exercise and muscular biopsy.

Study Design

Study Type
Interventional
Allocation
Non Randomized
Intervention Model
Parallel
Masking
None

Eligibility Criteria

Ages
40 Years to 70 Years (Adult, Older Adult)
Sex
Male
Accepts Healthy Volunteers
No

Inclusion Criteria

  • •Obese patients with a Body Mass Index (BMI) between 30 and 40 kg/m2
  • •Patients who do not practice physical exercise (Voorips index < 9)
  • •Age between 40 and 70 years- Male gender
  • •Fast blood glucose <1,10 g/l and no hypoglycemic treatment
  • •Signed informed consent
  • •Social security affiliation
  • •Absence of anti VIH, anti hepatitis C antibodies, and HBS antigen
  • •Normal biological tests
  • •Non smoking persons

Exclusion Criteria

  • •Patients who refuse the anti-VIH, anti-hepatitis C antibodies, and HBS antigens tests
  • •Patients treated by anticoagulant, b blockers, lipopenic, or anti-inflammatory.
  • •Patients with a contraindication to muscular exercise (retinopathy, coronaropathy, nephropathy) and to muscular biopsy
  • •Allergy to local anaesthetic

Outcomes

Primary Outcomes

lipid accumulation in skeletal muscle

Time Frame: 1 month

Secondary Outcomes

  • lipid accumulation in myotubes from obese patients(1 month)

Investigators

Sponsor Class
Other
Responsible Party
Sponsor

Study Sites (2)

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