Mannose Binding Lectin Gene Polymorphism Versus Microbial Virulence in the Pathogenesis of Vulvovaginal Candidiasis

• Conditions: Infection

• Registration Number: NCT04552210
• Lead Sponsor: Aljazeera Hospital

Brief Summary

The vaginal mucosa is inhabited by both fungal and bacterial microorganisms which normally co-exist with the host in a tightly regulated and commensal manner.

Detailed Description

Nevertheless, under certain circumstances, this co-existence can turn into a pathologic state followed by symptomatic disease

Study Timeline

• Study First Submitted: 2020-09-11
• Study First Submitted QC: 2020-09-11
• Study Start: 2020-09-16
• Study First Posted: 2020-09-17
• Status Verified: 2020-11
• Last Update Submitted: 2020-11-07
• Last Update Posted: 2020-11-10
• Primary Completion: 2020-12-15
• Study Completion: 2021-02-20

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 50

Inclusion Criteria

• 1. Married females in the reproductive age period. 2. Females complaining of vaginal discharge (whitish and scanty), itching, dyspareunia, pruritis, and signs of vulvovaginitis ie. erythema.

Exclusion Criteria

• females who attended the same clinic in the same period, matched the cases regarding the age group, without having Candida infection as confirmed by culture of vaginal swabs.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
the number of women who have mutation in MBL2 gene polymorphism	a month	women who have mutation in MBL2 gene polymorphism

Trial Locations

Locations (1)

Algazeerah; 🇪🇬 Giza, Egypt