Effect of corticosteroids and antioxidants on kidney transplantation outcome from brain-dead donors
- Conditions
- Condition 1: Kidney transplantation. Condition 2: Brain dead.Other disorders of central nervous system
- Registration Number
- IRCT2015071323192N1
- Lead Sponsor
- Isfahan university of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 68
1. The absence or incidence of malignancy or the history of malignancy or
2. The absence of specific diseases that affect organs, according to the history and clinical examination i.e. for example, patients with ESRD or systemic infection such asHIV, HTLV1, rubella, CMV and etc. . A history of diabetes and high blood pressure not absolute contraindications for organ donation.
3. The absence of high-risk behaviors, such as intravenous drug abuse or sexual organ donation.
4. Common tests: do they all donors is necessary. These tests should be in the range of Normal are as follows:
Na, K, BUN, Cr, CBC, ABO-Rh, VDRL, RPR, U/A, U/C, B/C, BS, HIV, Anti HTLV I, II, Anti HCV Ab, HBC Ab, HBS Ag, BHCG Toxo, CMV (Igm, IgG) EBV (Igm, IgG), HIV (Ag p 24)
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Il-1b, IL-6, TNF-a. Timepoint: Before and after intervention. Method of measurement: ELISA Kit.;MCP-1, HSP70, HMGb1. Timepoint: Before and after intervention. Method of measurement: ELISA Kit.;SCD86. Timepoint: Before and after intervention. Method of measurement: ELISA Kit.;TLR1, 2, 3, 4, 5, 6, 7, 8, 9. Timepoint: Before and after intervention. Method of measurement: Real-time PCR.;NK Cells. Timepoint: Before and after intervention. Method of measurement: ELISA Kit.;C3a, C5a. Timepoint: Before and after intervention. Method of measurement: ELISA Kit.
- Secondary Outcome Measures
Name Time Method Creatinin. Timepoint: after transplantation. Method of measurement: creatinin KIt.;Cystatin-C. Timepoint: after transplantation. Method of measurement: ELISA Kit.