Hemodynamic Optimization Based on a Dynamic Elastance Protocol
Not Applicable
Completed
- Conditions
- Fluid Management
- Registration Number
- NCT05187273
- Brief Summary
In this study investigators explore the effects of a dynamic elastance guided protocol compared to a stroke volume variation fluid therapy on lactate levels during major abdominal surgery. Hence investigators created two groups: in the intervention group fluids are given in fluid-responders (SVV \> 13%) based on high value of dynamic elastance (ie. Eadyn \> 0.9). In the standard group fluids are administered when SVV \> 13%.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 46
Inclusion Criteria
patients enrolled for major abdominal surgery
Exclusion Criteria
- end-stage renal disease
- severe heart dysfunction
- heart rhythm alterations
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SEQUENTIAL
- Primary Outcome Measures
Name Time Method lactate levels at the end of surgery
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie dynamic elastance-guided fluid therapy in major abdominal surgery?
How does dynamic elastance-guided fluid management compare to standard stroke volume variation protocols in reducing lactate levels?
Which biomarkers correlate with fluid responsiveness in intraoperative hemodynamic optimization using Eadyn values?
What are the potential adverse events associated with dynamic elastance-based fluid administration during major abdominal surgery?
Are there alternative hemodynamic monitoring technologies or protocols that could enhance fluid management in abdominal surgery?
Trial Locations
- Locations (1)
Andrea Russo
🇮🇹Rome, Italy
Andrea Russo🇮🇹Rome, Italy