The effect of spinal cord stimulation and dorsal root ganglion stimulation on histamine induced itch: an experimental pilot study

Recruiting

Conditions: experimentele pruritus
experimental pruritus
itch
10034606

Registration Number: NL-OMON49164

Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 12

Inclusion Criteria

- Good effect (* 50% decrease of pain) of spinal cord stimulation (SCS) or
dorsal root ganglion stimulation (DRGS) treatment.
- The area innervated by the SCS or DRGS must extend to a healthy, pain-free,
uninterrupted area of skin of at least 10x20cm
- Contralaterally, an equal, uninterrupted, healthy area of skin must be
available; this must not be innervated by the stimulator.
- Patient must have no objections against switching off his or her device, for
up to one hour.
- Age ><=18 years
- No ongoing itch perception

Exclusion Criteria

- Generalized skin disorder,
- Systemic disease associated with pruritus,
- Complex regional pain syndrome
- Allergy or hypersensitivity
- Contra-indication for histamine administration, such as mastocytosis
- Use of opioids
- Use of oral antihistamines, corticosteroids or other (immunosuppressive)
drugs that might prevent potential participants from developing a flare.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Itch intensity will be recorded using a visual analog scale (VAS). Patients*<br /><br>VAS score will be noted at baseline, after switching off of the<br /><br>neurostimulator, 15 minutes after application of histamine, and 1, 5, 10, 15<br /><br>and 30 minutes after the stimulator has been switched on. All measurements will<br /><br>be noted for both sides, separately.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The size of the flare will be measured at all timepoints after application of<br /><br>histamine. At all timepoints after histamine application, character and<br /><br>variance of itch perception will be determined, by means of a questionnaire.<br /><br>All measurements will be noted for both sides, separately.</p><br>