Hyaluronic Acid +Hydroxyapatite Vs Hydroxyapatite in Bone Regeneration

Not Applicable

Not yet recruiting

• Conditions: Bone Lesion; Bone Loss
• Interventions: Procedure: Hydroxyapatite alone; Procedure: hyaluronic acid added to hydroxyapetite

• Registration Number: NCT05957926
• Lead Sponsor: Cairo University

Brief Summary

Evaluation of the effect of hyaluronic acid with hydroxyapatite versus hydroxyapatite alone on bone regeneration following enucleation of mandibular odontogenic cyst.

Detailed Description

During cyst enucleation , There's resultant decrease in bone density especially in large defects .Therefore, it may be needed for a bone grafts and bone regenerative materials to improve quality of bone .The rationale is to evaluate hyaluronic acid with hydroxyapatite as a bone quality improvement material following cyst enucleation, which would provide significant bone regeneration. Hydroxyapatite is inorganic component of bone tissue used as bone graft, scaffolds, filler and cement for repair and regeneration of bone defect , and it is stimulate bone remodeling by generating surface active moieties or cell signaling process while Hyaluronic acid and it's derivatives has been widely used for bone regeneration and it has a good potential for osteogenesis and mineralization

Study Timeline

• Status Verified: 2023-07
• Study First Submitted: 2023-07-08
• Study First Submitted QC: 2023-07-14
• Study First Posted: 2023-07-24
• Last Update Submitted: 2023-09-11
• Last Update Posted: 2023-09-13
• Study Start: 2023-10-01
• Primary Completion: 2024-08-01
• Study Completion: 2025-01-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Patient in need of cyst removal .
• Both genders aged between 18-50 years .
• Size of lesion is ≤ 4 cm .
• Patients free from any systemic disease that may affect bone healing .

Exclusion criteria :

• Heavy smokers , alcohol intake .
• Poor oral hygiene .
• Patient with systemic disease that may affect bone healing .
• Pregnant women.
• Patient who are currently or have been under treatment using chemotherapy or radiotherapy
• Uncooperative patient .

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Hydroxyapatite alone	Hydroxyapatite alone	Hydroxyapatite is inorganic component of bone tissue used as bone graft, scaffolds, filler and cement for repair and regeneration of bone defect , and it stimulates bone remodeling by generating surface active moieties or cell signaling process
Hyaluronic acid + Hydroxyapatite	hyaluronic acid added to hydroxyapetite	hyaluronic acid is used for bone regeneration and it has a good potential for osteogenesis and mineralization so it can have synergistic effect when used with hydroxyapatite for bone regeneration after cyst enucleation

Primary Outcome Measures

Name	Time	Method
Bone density	6 months	It is assessed using CBCT to determine the density of bone after intervention

Secondary Outcome Measures

Name	Time	Method
postoperative pain	2 weeks	It is assessed by using visual analogue scale from 1-10

Trial Locations

Locations (1)

Faculty of Dentistry, Cairo University; 🇪🇬 Cairo, Egypt