Perioperative metabolome changes in patients undergoing general anaesthesia for tumor surgery
- Conditions
- General anaesthesiaC25Malignant neoplasm of pancreas
- Registration Number
- DRKS00016686
- Lead Sponsor
- niversitätsklinikum Heidelberg Klinik für Anästhesiologie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Suspended
- Sex
- All
- Target Recruitment
- 30
male; Age 18-70years; indication for whipple-surgery (pancreatic cancer surgery) for pancreatic cancer treatment; planned General anesthesia with or without epidural anaesthesia
female; incapacitated patients; dementia; psychotic disease; mental Retardation; neoadjuvant chemotherapy <3months before surgery; renal insufficiency (GFR <60ml/min); Diabetes type I or II with Need for drug therapy; autoimmune disorder (Lupus erythematodes, Sjögren Syndrome, Spondylitis alkylosans, CREST-Syndrome, sklerodermia, Morbus crohn, colitis ulcerosa, sarkoidose, goodpasture-syndrome, celiac disease, hashimoto-thyreoiditis, Morbus Basedow, autoimmune pancreatitis, multiple sklerosis, rheumatoid Arthritis); congenital immune disorders, iatrogene immune Suppression (Steroid therapy, Transplantation); blood transfusions <14days before surgery; therapy with immune modulating drugs (statines, Arginin, Coenzyme Q; Carnitin, Cyclosporin)
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Measurement of perioperative, longitudinal metabolic changes on oncologic patients by quantitative analysis of metabolites (amino acids, carnitines, sugars, phospholipids, sphingolipids, fatty acids, bile acids, zytokines) via mass spectrometry using internal Standards in patients receiving General anesthesia during pancreatic cancer surgery (whipple's surgery)
- Secondary Outcome Measures
Name Time Method Identification of possible anaesthesiologic factors that may influence metabolic changes. Generating further hypothesis for more detailed studies on the influence of anaesthesiologic procedures on cancer outcome.