Establishment and Application of Digital Diagnosis and Treatment System for Sarcopenia

Recruiting

• Conditions: Sarcopenia

• Registration Number: NCT06380777
• Lead Sponsor: Peking Union Medical College Hospital

Brief Summary

The goal of this observational study is to establish a digital diagnosis and treatment system for sarcopenia, integrating research outcomes into a unified approach encompassing a digital vaccine (early warning screening model), digital drug (intervention model associated with pathogenesis), and digital rehabilitation (preventive system combining early warning and treatment). This aims to create a digital visual tertiary prevention network for sarcopenia.

Research aims:

Evaluate the effectiveness of the digital vaccine through a cross-sectional epidemiological survey.

Establish a specialized cohort for sarcopenia through a longitudinal investigation, implementing the digital drug and digital rehabilitation interventions.

Participants will:

Engage in screening and assessment based on inclusion and exclusion criteria.

Be monitored longitudinally, with tailored interventions for those with muscle atrophy and regular follow-ups for at-risk individuals.

Key outcomes will focus on sarcopenia indicators, serum biomarkers, and clinical endpoints such as fracture rates, weakness classification, and quality of life.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-09-01
• Status Verified: 2024-04
• Study First Submitted: 2024-04-06
• Study First Submitted QC: 2024-04-21
• Last Update Submitted: 2024-04-21
• Study First Posted: 2024-04-24
• Last Update Posted: 2024-04-24
• Primary Completion: 2028-12-31
• Study Completion: 2028-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 10000

Inclusion Criteria

• Age ≥45 years;
• meeting sarcopenia diagnostic criteria;
• consent to participate in this study

Exclusion Criteria

• Age <45 years;
• patients in acute phase of chronic illness;
• infectious disease patients;
• people who lack of independent mobility;
• people who lack of communication or cognitive skills;
• people who refusal to participate in this study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Appendicular skeletal muscle mass index	Through study completion, an average of 6weeks	Defined as muscle mass (Unit: kg/m2)

Secondary Outcome Measures

Name	Time	Method
Gait speed	Through study completion, an average of 6weeks	Defined as physical performance (Unit: m/s)
Hand grip strength	Through study completion, an average of 6weeks	Defined as muscle strength (Unit: kg)

Trial Locations

Locations (1)

Peking Union Medical College Hospital; 🇨🇳 Beijing, Beijing, China