Effects of Dexmedetomidine on Oxygenation and Lung Mechanics in Morbidly Obese Patients Undergoing Bariatric Operations
Phase 4
Completed
- Conditions
- Restrictive Lung Disease
- Interventions
- Drug: Normal saline
- Registration Number
- NCT02843698
- Lead Sponsor
- Cairo University
- Brief Summary
The study aims to investigate the effect of dexmedetomidine on oxygenation and lung mechanics in morbidly obese patients
- Detailed Description
The patients of interest are morbid obese patients scheduled for bariatric surgery. Dexmeditomidine will be infused intraoperatively after induction of anesthesia. lung mechanics (dead space and compliance) as well as oxygenation (PF ratio) will be monitored intraoperatively and postoperatively
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 42
Inclusion Criteria
- Morbid obese (body mass index > 40) with documented restrictive lung disease scheduled to bariatric operation.
Exclusion Criteria
- Heart failure
- ِِِِArrhythmia
- Heart block
- Severe liver or kidney impairment.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Control group Normal saline Patients will receive normal saline Dexmedetomidine group Dexmedetomidine Patients will receive either, Dexmedetomidine (Precedex, Hospira, Lake forest, IL, USA) in a dose of (1ug/Kg LBW) bolus followed by 0.5ug/Kg continuous infusion for one hour
- Primary Outcome Measures
Name Time Method Oxygenation 2 hours assessed by P/F ratio
- Secondary Outcome Measures
Name Time Method Lung mechanics 2 hours lung compliance and dead space
arterial blood pressure 2 hours arterial blood pressure measured in mmHg
plateau airway pressure 2 hours plateau airway pressure measured in cmH2o
heart rate 2 hours number of heart beats per minute
Trial Locations
- Locations (1)
Cairo University
🇪🇬Cairo, Egypt