Differences in Behaviour Related to Dietary Habit, Self-medication and Nutraceuticals Use Among Italian and Spanish University Students: Relationship With Cardiovascular Risk Factors.
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 200
- 试验地点
- 3
- 主要终点
- Compare the prescription of drugs in Italian and Spanish university students
研究概览
简要总结
University students are considered a population class with a high risk of malnutrition and/or obesity, metabolic and cardiovascular diseases, with a tendency to misuse drugs and self-medication.
The interest in a healthy diet can lead to a psychological obsession known as orthorexia, frequent among students in the biomedical field and in the sports context.
The high levels of stress recorded in university students have been related to the use of drugs to enhance their cognitive abilities. The phenomenon of self-medication is one of the main problems for public health, with high levels recorded among students of health professions.
A high adherence to the Mediterranean diet seems to bring health benefits, with an impact even on the intestinal microbiota composition. Although several studies have investigated the effect of the Mediterranean diet on intestinal microbiota, little attention has been paid to the effect of this diet on the oral microbiota, one of the most relevant microbial habitats from a clinical point of view.
The aim of this study is to evaluate self-medication, adherence to the Mediterranean diet, the relationship between lifestyle and biomarkers of the metabolic and immunological status, and impact of eating habits on the oral microbiota composition.
Students, doctoral students, post-docs and specialists in the biomedical and pharmaceutical fields will be recruited in Italy (N = 200) and in Spain (N = 200). Data will be collected through questionnaires in order to evaluate self-medication, eating habits, level of physical activity, orthorexia and lifestyle of the subjects. The entire group will be evaluated with clinical parameters of metabolic status and the quality of saliva and urine. The latter will be determining factors for the selection of 50 Italian and 50 Spanish students, on which parameters of immunological and antioxidant status, cortisol, urinary phenols, and the composition of the oral microbiota will be evaluated.
Italian and Spanish students may have different eating habits and lifestyles. It is assumed that subjects with high adherence to the Mediterranean diet have a better metabolic and immunological status. Moreover, high rates of orthorexia are expected among students who practice sports. The composition of the oral microbiota could vary depending on the type of diet and consistently with the immunological status markers.
详细描述
Young people are considered a population at risk of nutritional deficiencies due to bad eating habits, found especially among university students. In fact, the latter tend to change their eating habits when they begin their university studies, with adherence to a typically western diet that includes low consumption of fish, fruit and vegetables, monounsaturated and polyunsaturated fatty acids, and an increase in consumption of sugars, alcohol and "fast food", with the consequent increase in this population class of the risk of malnutrition and/or obesity, metabolic and cardiovascular diseases. These changes are due to the lack of experience in meal planning, with a consequent increase in the frequency of meals away from home, to the increase in the number of snacks or meals skipped to respect the timetable of the lessons, to the easier access to the fast food and limited economic resources. Among the unhealthy behaviors adopted by the students, in addition to the wrong eating habits, there are also reduced physical activity, increased sedentariness, alcohol consumption and smoking.
Over the past 20 years there has been an increase in obesity rates among university students who, especially for medical students, are closely related to specific habits such as: skipping breakfast, attending fast food, low fruit and vegetables consumption, and easy access to unhealthy foods from the machines. Among the freshmen, especially those who live far from families and find themselves independent for the first time in their lives, higher rates of weight gain and higher levels of stress have been reported, responsible for changes in food choices. In fact, to control stress levels, individuals are encouraged to prefer foods that are high in fat. Therefore, university students should be seen as a group that requires special attention regarding health promotion, especially food.
However, the interest in a healthy diet can lead to a psychological obsession known as orthorexia (ortho = just, oreksis = appetite), which consists in the persistent concern of maintaining the self-imposed diet to improve one's health. Nutritionists/dieticians and students are the categories of population most affected by orthorexia, with a prevalence in Italian nutrition science students of 35.9%. The typical behaviors of orthorexia can be associated with a negative image of one's own body, despite the subject's strong interest in appropriate and healthy food choices. However, as a result of extreme restriction/concern over one's diet, orthorhexics would tend to eliminate whole groups of foods with consequent nutritional deficiencies, malnutrition and weight loss. Furthermore, the typical eating behavior of orthoressia is associated with intense physical activity, suggesting that students who practice sports have a greater tendency to develop this disorder.
The high levels of stress recorded in university students were also related to the use of smart drugs and "smart nutrients", which university students, especially those in medicine (74.7%), use to enhance their cognitive abilities. The phenomenon of self-medication is one of the main problems for public health, with only 48% of the population of the European Union using prescribed drugs. Among the students of health professions high levels of self-medication with antibiotics are recorded in the absence of indication. Another trend that is of particular concern is the increase in the use of antidepressants among young people, which many of them take after disappointments in academic performance and which have negative side effects such as weight gain , altered lipid profile and risk of diabetes. Another category of substances that young people abuse or otherwise misuse are amphetamines, and the co-intake of stimulants, alcohol or other drugs is also of concern. Indeed, a recent study carried out on Italian and Spanish pharmacy students showed that Spaniards have a high percentage of drug use and that 38.4% of subjects take them in conjunction with alcohol; instead, Italian students have revealed that they rarely turn to the pharmacist and rely more on the advice of family or friends.
The university years therefore represent a period marked not only by food problems but also by stress, anxiety, depression and other psychological problems. However, it emerged that a high adherence to the Mediterranean diet would bring benefits at the cognitive level, with an improvement in the states of depression and anxiety and a better academic result. In addition to a healthy diet, even moderate and regular physical activity (90 minutes a week) has been shown to reduce levels of anxiety and depression with improved well-being and self-esteem. For this reason it is essential to promote this lifestyle among university students.
研究设计
- 研究类型
- Observational
- 观察模型
- Ecologic Or Community
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 35 Years(Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •university students, doctoral students, post-docs and post-graduate students in biomedical and pharmaceutical sciences
排除标准
- •age <18 years or inability to sign informed consent.
结局指标
主要结局
Compare the prescription of drugs in Italian and Spanish university students
时间窗: One year
The percentage of subjects who resort to self-medication and the use of drugs will be evaluated on the basis of the data reported in a specific online questionnaire
Compare the use of alcohol in Italian and Spanish university students
时间窗: One year
The use of alcoholic beverages will be evaluated with the questionnaire AUDIT, which will be included in the questionnaire on "voluptuous habits"
Compare the use of energy drinks in Italian and Spanish university students
时间窗: One year
The use of energy drinks will be evaluated on the basis of the data reported in a specific online questionnaire
Compare the use of supplements, dietary products and/or other types of nutraceuticals in Italian and Spanish university students
时间窗: One year
The use of supplements, dietary products and / or other types of nutraceuticals will be evaluated on the basis of the data reported in a specific online questionnaire
Compare the adherence to the Mediterranean diet in Italian and Spanish university students
时间窗: One year
The degree of adherence to the Mediterranean diet (online questionnaire) will be calculated with two different scores: the Mediterranean Diet Score (MDS) evaluated through the validated 14-item questionnaire of the PREDIMED study and the MEDScore (Score-55) proposed by Panagiotakos with the dedicated software. The latter, unlike the first, includes the consumption of unrefined cereals. We will compare the baseline characteristics of participants according to three categories of adherence to the Mediterranean diet (\> or egual to 5, 6-9 and \> or egual to 10 points of the 14-item questionnaire). At each question of the 14-item questionnaire will be assigned a score of 0 or 1 on the basis of the answer. Panagiotakos et al. have already proposed a diet score that evaluates adherence to the Mediterranean diet through a large-scale (from 0 to 55).
Compare cardiovascular risk factors (obesity) in Italian and Spanish university students
时间窗: Two year
Measurements of weight (Kg), height (m) (portable mechanical Stadiometer), lean mass and fat mass will be recorded on the data collection form. In particular, the latter will be measured both by means of the OMRON BF-511 body analysis impedance balance and by plicometry. Weight and height will be combined to report BMI in kg/m\^2
Compare cardiovascular risk factors (hypertension) in Italian and Spanish university students
时间窗: Two year
Blood pressure will be recorded on the data collection form
Compare cardiovascular risk factors (hyperglycemia and dyslipidemia) in Italian and Spanish university students
时间窗: Two year
The clinical metabolic status parameters will be evaluated by: self-diagnosis of capillary blood sampling (cholesterol, triglycerides and glycaemia by means of Multicare IN) and a dedicated ELISA kit for saliva sample insulin, based on saliva quality.
Compare ketosis in Italian and Spanish university students
时间窗: Two year
The clinical metabolic status parameter will be evaluated by self-diagnosis of capillary blood sampling (ketones by means of ON Call GK Dual)
次要结局
- Register other characteristics of interest (vaccinations and opinion on vaccines)(One year)
- Compare the type of meals consumed outside home in Italian and Spanish university students(One year)
- Register other characteristics of interest (pathologies)(One year)
- Register other characteristics of interest (anxiety/depressive symptoms)(One year)
- Register other characteristics of interest (eating disorders)(One year)
- Compare salivary microbiota in a sub-group of non-smoking Italian and Spanish students(Two year)
- Compare the frequency of meals consumed outside home in Italian and Spanish university students(One year)
- Compare the type of food/beverages consumed in Italian and Spanish university students(One year)
- Compare the consumption of food/beverages in Italian and Spanish university students(One year)
- Compare eating habits in a sub-group of non-smoking Italian and Spanish students(Two year)
- Compare and evaluate the level of physical activity in Italian and Spanish university students(One year)
- Compare the adherence to special dietary regimes (vegetarian diet, ketogenic etc) in Italian and Spanish university students(One year)
- Compare and evaluate the percentage of subjects with orthorexia nervosa in Italian and Spanish university students(One year)
- Compare salivary IgA levels in a sub-group of non-smoking Italian and Spanish students(Two year)
- Register other characteristics of interest (food neophobia)(One year)
- Compare salivary IL-6 levels in a sub-group of non-smoking Italian and Spanish students(Two year)
- Compare salivary cortisol levels in a sub-group of non-smoking Italian and Spanish students(Two year)
研究者
Maura Palmery
Associate Professor of Pharmacology
University of Roma La Sapienza
