Comparison of endothelial function by EndoPat® measurements in patients with primary Sjögren's syndrome to healthy controls and patients with systemic sclerosis
Recruiting
- Conditions
- M35.0Sicca syndrome [Sjögren]
- Registration Number
- DRKS00032430
- Lead Sponsor
- Medizinische Hochschule Hannover
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 110
Inclusion Criteria
Given consent with capacity to consent present.
Meet current EULAR classification criteria for primary Sjögren's syndrome or systemic sclerosis.
Exclusion Criteria
current pregnancy
not fulfilling the inclusion criteria
lack of consent and capacity to consent
Control patients must not have an underlying inflammatory disease
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Endothelial function using RHI<br><br>Detection of plaques in the common carotid artery, intima-media thickness of the common carotid artery, ankle-brachial index, pulse wave velocity of the common carotid artery and radial artery, and pulse wave analysis of the radial artery.
- Secondary Outcome Measures
Name Time Method Comparison with disease severity and disease parameters using ESSDAI and ESSPRI; <br>Comparison with disease-specific antibodies: ANA, RF, alpha-fodrin, Ro-AK, La-AK, hypergammaglobulinemia, IgG4 <br><br>Cardiovascular risk factors, atherosclerotic end disease (CAD, pAD, stroke), disease activity, organ manifestations in pSS, evidence of novel biomarkers.
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular pathways link endothelial dysfunction in primary Sjögren's syndrome to systemic sclerosis as measured by EndoPat®?
How does EndoPat®-derived endothelial function correlate with standard-of-care biomarkers in autoimmune rheumatic diseases?
Which inflammatory biomarkers predict impaired EndoPat® measurements in primary Sjögren's syndrome versus systemic sclerosis patients?
What adverse vascular events are associated with primary Sjögren's syndrome compared to systemic sclerosis in observational endothelial studies?
Are there non-pharmacological interventions improving endothelial function in primary Sjögren's syndrome beyond EndoPat® monitoring?