Improving the Detection of Active Tuberculosis in Accident and Emergency (A&E) Departments
试验速览
- 阶段
- 不适用
- 入组人数
- 1,000
- 试验地点
- 3
- 主要终点
- xray diagnosis of active TB
研究概览
简要总结
Tuberculosis (TB) control remains a public health challenge. Many people in the UK do not have a general practitioner (GP) registration and their only interaction with the NHS is via Accident and Emergency (A&E) Departments of hospitals. This is often the case for those in hard to reach groups, who are also those often at highest risk of TB. This study seeks to assess whether A&E Departments are effective sites for the identification and onward management of TB, both in its latent and active forms.
详细描述
This proposal is focused upon early diagnosis, referral and treatment of active tuberculosis, which has two key components: 1) ensuring optimal outcome for individuals; 2) contributing to disease control in public health terms by preventing further spread.
A&E Departments are an important point of testing and referral for the client group that constitute those at greatest risk, as for many this will be their only interaction with the health service. Currently, A&E Departments contribute about 20% of those diagnosed with TB. The majority of these individuals are most likely to have presented with symptoms indicative of disease, compared to those attending for other reasons who would have been unlikely to have been tested or referred.
This study will seek to evaluate specific measures currently being undertaken by Public Health England and the NHS to control TB as well as investigate whether case finding for active TB in A&E departments would improve TB control. The economic impact of these interventions will be evaluated, providing a measure of its value for money.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 16 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Individuals 16 years or older, who are new entrants from high incidence countries who have arrived in the UK within the past 2 years or those born in high incidence countries who entered the UK more than five years ago, but have spent more than one year (cumulative) in the past five years in a high incidence country.
- •Those with social risk factors who have signs and/or symptoms of TB.
排除标准
- •Individuals who are under 16 years
- •Individuals who were born in the UK or a low incidence countries and do not have risk factors
结局指标
主要结局
xray diagnosis of active TB
时间窗: 1 year
clinical signs and symptoms on xray
次要结局
- diagnosis of latent TB(1 year)
研究者
Jo Southern
Clinical Research Lead
Public Health England