The study is done to compare the effect of nalbuphine and clonidine when added to hyperbaric Bupivacaine Intrathecally in lower abdominal and lower limb surgeries

Not yet recruiting

• Conditions: Other and unspecified acute appendicitis,

• Registration Number: CTRI/2021/09/036615
• Lead Sponsor: Dr Simmy John

Brief Summary

It is a randomized,prospective, comparative, double blinded,observational study where in Intrathecal Nalbuphine and Clonidine  are compared as adjuvants to hyperbaric Bupivacaine in Lower abdominal and Lower Limb surgeries.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-09-20
• Last Update Posted: 2021-12-09

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

ASA I and II Patients posted for lower abdominal and lower limb surgeries Weight of the patient being in normal range for that age and sex Patients who are not on any antihypertensive, antiplatelet,fibrinolytic or anticoagulant drugs Patients who give informed written consent and are willing to be a part of the study.

Exclusion Criteria

1. Patients with pre existing cardiovascular disease ( IHD, hypertension, valvular heart disease), deranged liver functions or renal functions 2) Patients with any Neurological and psychiatric disorders 3) Patients with any contra indication for neuraxial blockade 4) Patients posted for emergency procedures 5) History of allergy to any of the drugs being used under study 6) Unwilling patients.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
“COMPARISION OF INTRATHECAL NALBUPHINE VS CLONIDINE AS	0 minute, 1 minute, 2 minutes, 5 minutes, 10 minutes, 15 minutes and 30 minutes
ADJUVANTS TO BUPIVACAINE IN LOWER ABDOMINAL	0 minute, 1 minute, 2 minutes, 5 minutes, 10 minutes, 15 minutes and 30 minutes
AND LOWER LIMB SURGERIESâ€	0 minute, 1 minute, 2 minutes, 5 minutes, 10 minutes, 15 minutes and 30 minutes

Secondary Outcome Measures

Name	Time	Method
To study and compare changes in various physiological and pharmacological parameters as well	as results achieved, when clonidine is used as adjuvant to intrathecal 0.5% Bupivacaine during Spinal anaesthesia for lower abdominal and lower limb surgeries.

Trial Locations

Locations (1)

Dr D Y Patil Medical College Hospital and research centre; 🇮🇳 Pune, MAHARASHTRA, India

Dr D Y Patil Medical College Hospital and research centre

🇮🇳Pune, MAHARASHTRA, India

Simmy John

Principal investigator

9995485404

simmyjohn1991@gmail.com