Comparing the effectiveness of Hypofractionated Radiotherapy with Conventional Radiotherapy in High Grade Glioma Treatment
Phase 2
- Conditions
- Health Condition 1: C719- Malignant neoplasm of brain, unspecified
- Registration Number
- CTRI/2024/01/061808
- Lead Sponsor
- AIIMS Raipur
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1 Pathologically proven high grade glioma (HGG).
2 Age = 50 years
3 Adequate routine blood investigations including complete blood count (CBC), liver function test (LFT) and renal function test (RFT)
Exclusion Criteria
Previous history of radiation to brain
Patient with metastatic disease
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method More patients treated with hypofractionated radiotherapy schedule will be able to complete treatment when compared to patients treated with the conventional schedule. <br/ ><br> <br/ ><br>The total dose given via hypofractionated schedule will be equivalent to the dose given via conventional fractionation (calculated from BED formula), hence will show a similar response. <br/ ><br>Timepoint: at treatment completion, 4 weeks, 8 weeks, 12 weeks, 16 weeks, 20 weeks and 24 weeks post treatment completion
- Secondary Outcome Measures
Name Time Method Patients will be followed up post treatment and treatment toxicity assessment (RTOG criteria), neurological assessment (NANO criteria) and quality of life (QoL using QLQ- BN 20 assessment form)Timepoint: Baseline, Treatment completion, 1,2,3,4,5,6 months post treatment